GO Annotations Graph

• Symbol: Smpd4
• Name: sphingomyelin phosphodiesterase 4
• ID: MGI:1924876

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	IDA	J:292540
Molecular Function	GO:0050290	sphingomyelin phosphodiesterase D activity	ISS	J:116417
Molecular Function	GO:0050290	sphingomyelin phosphodiesterase D activity	ISO	J:164563
Molecular Function	GO:0050290	sphingomyelin phosphodiesterase D activity	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISS	J:116417
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:292540
Cellular Component	GO:0005794	Golgi apparatus	ISS	J:116417
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005635	nuclear envelope	IDA	J:276404
Cellular Component	GO:0005640	nuclear outer membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0042383	sarcolemma	IDA	J:292540
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Cellular Component	GO:0005802	trans-Golgi network	ISS	J:116417
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA	J:292540
Biological Process	GO:0046513	ceramide biosynthetic process	IDA	J:292540
Biological Process	GO:0046513	ceramide biosynthetic process	ISO	J:164563
Biological Process	GO:0046513	ceramide biosynthetic process	IBA	J:265628
Biological Process	GO:0007029	endoplasmic reticulum organization	ISO	J:164563
Biological Process	GO:0046475	glycerophospholipid catabolic process	ISO	J:164563
Biological Process	GO:0046475	glycerophospholipid catabolic process	IBA	J:265628
Biological Process	GO:0001701	in utero embryonic development	IMP	J:240631
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006685	sphingomyelin catabolic process	IDA	J:292540
Biological Process	GO:0006685	sphingomyelin catabolic process	ISS	J:116417
Biological Process	GO:0006685	sphingomyelin catabolic process	ISO	J:164563
Biological Process	GO:0006685	sphingomyelin catabolic process	IBA	J:265628