GO Annotations Graph

• Symbol: Orai1
• Name: ORAI calcium release-activated calcium modulator 1
• ID: MGI:1925542

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0005246	calcium channel regulator activity	IMP	J:284285
Molecular Function	GO:0005246	calcium channel regulator activity	ISO	J:327474
Molecular Function	GO:0005246	calcium channel regulator activity	ISO	J:327475
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0099103	channel activator activity	ISO	J:327474
Molecular Function	GO:0099103	channel activator activity	IMP	J:284285
Molecular Function	GO:0099103	channel activator activity	ISO	J:327475
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	ISO	J:327474
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IMP	J:284285
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	ISO	J:327475
Molecular Function	GO:0005515	protein binding	IPI	J:203715
Molecular Function	GO:0005515	protein binding	IPI	J:121458
Molecular Function	GO:0005515	protein binding	IPI	J:160619
Molecular Function	GO:0015279	store-operated calcium channel activity	ISO	J:164563
Molecular Function	GO:0015279	store-operated calcium channel activity	ISO	J:155856
Molecular Function	GO:0015279	store-operated calcium channel activity	IBA	J:265628
Molecular Function	GO:0015279	store-operated calcium channel activity	ISO	J:327474
Molecular Function	GO:0015279	store-operated calcium channel activity	IMP	J:284285
Molecular Function	GO:0015279	store-operated calcium channel activity	ISO	J:327475
Molecular Function	GO:0015279	store-operated calcium channel activity	ISO	J:295079
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:203715
Cellular Component	GO:0071944	cell periphery	ISO	J:295079
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:121458
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:327474
Cellular Component	GO:0005886	plasma membrane	IDA	J:121458
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IPI	J:160619
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0070509	calcium ion import	IDA	J:203715
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0017156	calcium-ion regulated exocytosis	ISO	J:295079
Biological Process	GO:0035585	calcium-mediated signaling using extracellular calcium source	ISO	J:295079
Biological Process	GO:0051649	establishment of localization in cell	ISO	J:295079
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:284285
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	ISO	J:327475
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:284285
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	ISO	J:327475
Biological Process	GO:0061180	mammary gland epithelium development	IMP	J:203715
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	ISO	J:327475
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:284285
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	ISO	J:164563
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:284285
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:327475
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0002115	store-operated calcium entry	ISO	J:155856
Biological Process	GO:0002115	store-operated calcium entry	ISO	J:164563
Biological Process	GO:0002115	store-operated calcium entry	IBA	J:265628
Biological Process	GO:0002115	store-operated calcium entry	ISO	J:295079
Biological Process	GO:0002115	store-operated calcium entry	IGI	J:121458
Biological Process	GO:0002115	store-operated calcium entry	IGI	J:160619