GO Annotations Graph

• Symbol: Nol3
• Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
• ID: MGI:1925938

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0089720	caspase binding	ISO	J:155856
Molecular Function	GO:0089720	caspase binding	ISO	J:164563
Molecular Function	GO:0089720	caspase binding	IBA	J:265628
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA	J:265628
Molecular Function	GO:0035877	death effector domain binding	IPI	J:217283
Molecular Function	GO:0035877	death effector domain binding	ISO	J:155856
Molecular Function	GO:0035877	death effector domain binding	IBA	J:265628
Molecular Function	GO:0005123	death receptor binding	IPI	J:218360
Molecular Function	GO:0005123	death receptor binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:217283
Molecular Function	GO:0005515	protein binding	IPI	J:105727
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:217283
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IDA	J:87688
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0016528	sarcoplasm	IDA	J:87688
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:193803
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	IMP	J:121501
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0097340	inhibition of cysteine-type endopeptidase activity	ISO	J:155856
Biological Process	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IMP	J:211017
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0006376	mRNA splice site selection	ISO	J:164563
Biological Process	GO:0045445	myoblast differentiation	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:193803
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:121501
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1903073	negative regulation of death-inducing signaling complex assembly	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:155856
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	ISO	J:155856
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0051562	negative regulation of mitochondrial calcium ion concentration	ISO	J:155856
Biological Process	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process	IMP	J:211017
Biological Process	GO:0014736	negative regulation of muscle atrophy	IMP	J:211017
Biological Process	GO:0060547	negative regulation of necrotic cell death	IMP	J:218360
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903215	negative regulation of protein targeting to mitochondrion	ISO	J:155856
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	IBA	J:265628
Biological Process	GO:0010664	negative regulation of striated muscle cell apoptotic process	IMP	J:211017
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:218360
Biological Process	GO:0051259	protein complex oligomerization	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:143120
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	IMP	J:218360
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:155856
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	IMP	J:143120
Biological Process	GO:0014876	response to injury involved in regulation of muscle adaptation	IMP	J:143120
Biological Process	GO:0002931	response to ischemia	IMP	J:121501
Biological Process	GO:0048659	smooth muscle cell proliferation	ISO	J:155856