GO Annotations Graph

• Symbol: Stap1
• Name: signal transducing adaptor family member 1
• ID: MGI:1926193

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005157	macrophage colony-stimulating factor receptor binding	IPI	J:144524
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:73112
Molecular Function	GO:0005515	protein binding	IPI	J:64951
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:64951
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:144524
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	IBA	J:265628
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:144524
Cellular Component	GO:0034451	centriolar satellite	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:138112
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:144524
Biological Process	GO:0030099	myeloid cell differentiation	TAS	J:64951
Biological Process	GO:0010760	negative regulation of macrophage chemotaxis	IMP	J:144524
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	IMP	J:144524
Biological Process	GO:1904140	negative regulation of microglial cell migration	IMP	J:144524
Biological Process	GO:0042326	negative regulation of phosphorylation	IDA	J:144524
Biological Process	GO:1900028	negative regulation of ruffle assembly	IMP	J:144524
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	IMP	J:144524
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:144524
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:144524
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IDA	J:144524
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IDA	J:144524
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:144524
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:64951