GO Annotations Graph

• Symbol: Cd274
• Name: CD274 antigen
• ID: MGI:1926446

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:182372
Molecular Function	GO:0005515	protein binding	IPI	J:139033
Molecular Function	GO:0005515	protein binding	IPI	J:263399
Molecular Function	GO:0005515	protein binding	IPI	J:277405
Molecular Function	GO:0005515	protein binding	IPI	J:94873
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:94873
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0055038	recycling endosome membrane	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO	J:164563
Biological Process	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	ISO	J:164563
Biological Process	GO:0032693	negative regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0042130	negative regulation of T cell proliferation	IBA	J:265628
Biological Process	GO:0042130	negative regulation of T cell proliferation	IDA	J:114496
Biological Process	GO:1903556	negative regulation of tumor necrosis factor superfamily cytokine production	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:1905404	positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	IBA	J:265628
Biological Process	GO:0002845	positive regulation of tolerance induction to tumor cell	ISO	J:164563
Biological Process	GO:0034097	response to cytokine	ISO	J:164563
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0031295	T cell costimulation	ISO	J:164563
Biological Process	GO:0031295	T cell costimulation	IBA	J:265628
Biological Process	GO:1901998	toxin transport	IMP	J:197389