GO Annotations Graph

• Symbol: Gucy1a1
• Name: guanylate cyclase 1, soluble, alpha 1
• ID: MGI:1926562

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	ISO	J:155856
Molecular Function	GO:0047805	cytidylate cyclase activity	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0004383	guanylate cyclase activity	ISO	J:164563
Molecular Function	GO:0004383	guanylate cyclase activity	IBA	J:265628
Molecular Function	GO:0020037	heme binding	IEA	J:72247
Molecular Function	GO:0043167	ion binding	ISO	J:155856
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016849	phosphorus-oxygen lyase activity	IEA	J:72247
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:249777
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:249777
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:249777
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:249777
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	ISO	J:164563
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	ISO	J:155856
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:249777
Biological Process	GO:0006182	cGMP biosynthetic process	ISO	J:164563
Biological Process	GO:0006182	cGMP biosynthetic process	IBA	J:265628
Biological Process	GO:0006182	cGMP biosynthetic process	IMP	J:110362
Biological Process	GO:0019934	cGMP-mediated signaling	IBA	J:265628
Biological Process	GO:0009190	cyclic nucleotide biosynthetic process	IEA	J:72247
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0007263	nitric oxide mediated signal transduction	IMP	J:110362
Biological Process	GO:0007263	nitric oxide mediated signal transduction	IMP	J:110362
Biological Process	GO:0038060	nitric oxide-cGMP-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction	IMP	J:110362
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:110362
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	IMP	J:110362
Biological Process	GO:0070482	response to oxygen levels	IBA	J:265628
Biological Process	GO:0098925	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IMP	J:249777
Biological Process	GO:0098925	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IMP	J:249777
Biological Process	GO:0098925	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IDA	J:249777
Biological Process	GO:0098925	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IDA	J:249777