GO Annotations Graph

• Symbol: Huwe1
• Name: HECT, UBA and WWE domain containing 1
• ID: MGI:1926884

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0006284	base-excision repair	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:161386
Biological Process	GO:0032922	circadian regulation of gene expression	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0016574	histone ubiquitination	ISO	J:164563
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	ISO	J:164563
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:161386
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000