GO Annotations Graph

• Symbol: Calcrl
• Name: calcitonin receptor-like
• ID: MGI:1926944

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1990409	adrenomedullin binding	ISO	J:164563
Molecular Function	GO:0001605	adrenomedullin receptor activity	ISO	J:164563
Molecular Function	GO:0001605	adrenomedullin receptor activity	IBA	J:265628
Molecular Function	GO:0001635	calcitonin gene-related peptide receptor activity	ISO	J:164563
Molecular Function	GO:0001635	calcitonin gene-related peptide receptor activity	IBA	J:265628
Molecular Function	GO:0001635	calcitonin gene-related peptide receptor activity	IGI	J:30368
Molecular Function	GO:0004948	calcitonin receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:1903143	adrenomedullin receptor complex	ISO	J:164563
Cellular Component	GO:1990406	CGRP receptor complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0098992	neuronal dense core vesicle	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:30368
Biological Process	GO:1990410	adrenomedullin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IMP	J:106927
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0071329	cellular response to sucrose stimulus	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:62792
Biological Process	GO:0007507	heart development	IMP	J:106927
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:106927
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	IMP	J:106927
Biological Process	GO:0015031	protein transport	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0048659	smooth muscle cell proliferation	IMP	J:106927
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	IMP	J:106927