GO Annotations Graph

• Symbol: Trpv4
• Name: transient receptor potential cation channel, subfamily V, member 4
• ID: MGI:1926945

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	ISO	J:155856
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:155856
Molecular Function	GO:0005262	calcium channel activity	IMP	J:196099
Molecular Function	GO:0005262	calcium channel activity	IMP	J:188264
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IDA	J:82577
Molecular Function	GO:0005262	calcium channel activity	ISO	J:155856
Molecular Function	GO:0005262	calcium channel activity	IBA	J:265628
Molecular Function	GO:0005262	calcium channel activity	IDA	J:87276
Molecular Function	GO:0005262	calcium channel activity	IDA	J:65451
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005034	osmosensor activity	IDA	J:65451
Molecular Function	GO:0005034	osmosensor activity	IMP	J:84258
Molecular Function	GO:0005515	protein binding	IPI	J:169095
Molecular Function	GO:0005515	protein binding	IPI	J:277901
Molecular Function	GO:0005515	protein binding	IPI	J:196099
Molecular Function	GO:0005515	protein binding	IPI	J:200424
Molecular Function	GO:0005515	protein binding	IPI	J:277901
Molecular Function	GO:0005515	protein binding	IPI	J:162941
Molecular Function	GO:0005515	protein binding	IPI	J:87276
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IPI	J:82577
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	IPI	J:82577
Molecular Function	GO:0015275	stretch-activated, monoatomic cation-selective, calcium channel activity	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	IDA	J:162941
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005929	cilium	IBA	J:265628
Cellular Component	GO:0005929	cilium	IDA	J:99441
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0005881	cytoplasmic microtubule	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0030175	filopodium	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:162941
Cellular Component	GO:0005886	plasma membrane	IDA	J:82577
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:87276
Cellular Component	GO:0032587	ruffle membrane	ISO	J:155856
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	IBA	J:265628
Biological Process	GO:0097497	blood vessel endothelial cell delamination	ISO	J:164563
Biological Process	GO:0070509	calcium ion import	ISO	J:155856
Biological Process	GO:0070509	calcium ion import	IDA	J:82577
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:1902656	calcium ion import into cytosol	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	ISO	J:164563
Biological Process	GO:0007043	cell-cell junction assembly	IMP	J:162941
Biological Process	GO:0071476	cellular hypotonic response	ISO	J:164563
Biological Process	GO:0071476	cellular hypotonic response	IDA	J:82577
Biological Process	GO:0071477	cellular hypotonic salinity response	IMP	J:188264
Biological Process	GO:0034605	cellular response to heat	IMP	J:196099
Biological Process	GO:0071470	cellular response to osmotic stress	IMP	J:196099
Biological Process	GO:0043622	cortical microtubule organization	ISO	J:155856
Biological Process	GO:0002024	diet induced thermogenesis	IMP	J:188264
Biological Process	GO:0097009	energy homeostasis	IMP	J:188264
Biological Process	GO:0042593	glucose homeostasis	IMP	J:188264
Biological Process	GO:0042538	hyperosmotic salinity response	IMP	J:84258
Biological Process	GO:0006971	hypotonic response	ISO	J:155856
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:196099
Biological Process	GO:0046785	microtubule polymerization	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	ISO	J:155856
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	ISO	J:164563
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	IMP	J:188264
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:188264
Biological Process	GO:0007231	osmosensory signaling pathway	IDA	J:82577
Biological Process	GO:0007231	osmosensory signaling pathway	IBA	J:265628
Biological Process	GO:0007231	osmosensory signaling pathway	IDA	J:65451
Biological Process	GO:0007231	osmosensory signaling pathway	IMP	J:84258
Biological Process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	IMP	J:188264
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP	J:188264
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:188264
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:188264
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:188264
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:188264
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:188264
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IMP	J:188264
Biological Process	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	IMP	J:188264
Biological Process	GO:0031117	positive regulation of microtubule depolymerization	ISO	J:155856
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	IMP	J:188264
Biological Process	GO:0045989	positive regulation of striated muscle contraction	ISO	J:155856
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:155856
Biological Process	GO:0043117	positive regulation of vascular permeability	IMP	J:224727
Biological Process	GO:1903715	regulation of aerobic respiration	IMP	J:188264
Biological Process	GO:0047484	regulation of response to osmotic stress	IMP	J:84258
Biological Process	GO:0032868	response to insulin	IMP	J:188264
Biological Process	GO:0006970	response to osmotic stress	IDA	J:65451
Biological Process	GO:0006970	response to osmotic stress	IPI	J:87276
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0030103	vasopressin secretion	IMP	J:84258