Mettl3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
MGI:1927165

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IEA	J:72247
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	IMP	J:249262
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	IMP	J:203416
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	IBA	J:265628
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	IDA	J:207885
Molecular Function	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	ISO	J:70548
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:207885
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0008173	RNA methyltransferase activity	ISO	J:164563
Molecular Function	GO:1904047	S-adenosyl-L-methionine binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:319950
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:250428
Cellular Component	GO:0005634	nucleus	ISO	J:70548
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	IDA	J:261823
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	ISO	J:164563
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	IBA	J:265628
Biological Process	GO:0006382	adenosine to inosine editing	IMP	J:219587
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0007623	circadian rhythm	IMP	J:203416
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	ISO	J:164563
Biological Process	GO:0021861	forebrain radial glial cell differentiation	IMP	J:247703
Biological Process	GO:0042063	gliogenesis	IMP	J:247703
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:0006402	mRNA catabolic process	IMP	J:247703
Biological Process	GO:0006402	mRNA catabolic process	IMP	J:249262
Biological Process	GO:0006402	mRNA catabolic process	IMP	J:248553
Biological Process	GO:0061157	mRNA destabilization	IMP	J:248553
Biological Process	GO:0061157	mRNA destabilization	IMP	J:247703
Biological Process	GO:0061157	mRNA destabilization	IMP	J:219587
Biological Process	GO:0061157	mRNA destabilization	IMP	J:219614
Biological Process	GO:0061157	mRNA destabilization	IMP	J:249262
Biological Process	GO:0061157	mRNA destabilization	IMP	J:207885
Biological Process	GO:0080009	mRNA methylation	IDA	J:247703
Biological Process	GO:0080009	mRNA methylation	ISO	J:164563
Biological Process	GO:0080009	mRNA methylation	IMP	J:219587
Biological Process	GO:0080009	mRNA methylation	IMP	J:203416
Biological Process	GO:0080009	mRNA methylation	NAS	J:319950
Biological Process	GO:0080009	mRNA methylation	IMP	J:219614
Biological Process	GO:0080009	mRNA methylation	IMP	J:249262
Biological Process	GO:0080009	mRNA methylation	IBA	J:265628
Biological Process	GO:0080009	mRNA methylation	IDA	J:207885
Biological Process	GO:0016556	mRNA modification	ISO	J:70548
Biological Process	GO:0006397	mRNA processing	IMP	J:203416
Biological Process	GO:0000398	mRNA splicing, via spliceosome	IMP	J:219587
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048477	oogenesis	IMP	J:299108
Biological Process	GO:1903679	positive regulation of cap-independent translational initiation	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0031053	primary miRNA processing	ISO	J:164563
Biological Process	GO:0051445	regulation of meiotic cell cycle	IMP	J:250433
Biological Process	GO:0045580	regulation of T cell differentiation	IMP	J:249262
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0001510	RNA methylation	IMP	J:250428
Biological Process	GO:0001510	RNA methylation	IMP	J:248553
Biological Process	GO:0001510	RNA methylation	ISO	J:164563
Biological Process	GO:0001510	RNA methylation	IMP	J:250433
Biological Process	GO:0001510	RNA methylation	ISO	J:70548
Biological Process	GO:0007283	spermatogenesis	IMP	J:250433
Biological Process	GO:0007283	spermatogenesis	IMP	J:250428
Biological Process	GO:0007283	spermatogenesis	IMP	J:299108
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:219614
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:207885
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:219587

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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