GO Annotations Graph

• Symbol: Smpd3
• Name: sphingomyelin phosphodiesterase 3, neutral
• ID: MGI:1927578

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:218412
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	IDA	J:204092
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	IDA	J:218412
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	IDA	J:100158
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	IDA	J:190369
Molecular Function	GO:0070300	phosphatidic acid binding	IDA	J:292528
Molecular Function	GO:0001786	phosphatidylserine binding	IDA	J:292528
Molecular Function	GO:0004620	phospholipase activity	IBA	J:265628
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:245374
Molecular Function	GO:0005515	protein binding	IPI	J:217267
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	IDA	J:292528
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	IMP	J:97284
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	IDA	J:62281
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:62281
Cellular Component	GO:0000137	Golgi cis cisterna	IDA	J:97284
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:292528
Cellular Component	GO:0005886	plasma membrane	IDA	J:218412
Biological Process	GO:0014824	artery smooth muscle contraction	ISO	J:155856
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:212995
Biological Process	GO:0060348	bone development	IMP	J:236167
Biological Process	GO:0098868	bone growth	IMP	J:213345
Biological Process	GO:0098868	bone growth	IMP	J:122927
Biological Process	GO:0030282	bone mineralization	IDA	J:176975
Biological Process	GO:0030282	bone mineralization	IMP	J:213345
Biological Process	GO:0030282	bone mineralization	IMP	J:176975
Biological Process	GO:0051216	cartilage development	IMP	J:122827
Biological Process	GO:0051216	cartilage development	IDA	J:236167
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:202378
Biological Process	GO:0071286	cellular response to magnesium ion	IDA	J:204092
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	IMP	J:158723
Biological Process	GO:1901653	cellular response to peptide	IMP	J:236167
Biological Process	GO:0034614	cellular response to reactive oxygen species	IMP	J:122383
Biological Process	GO:0071461	cellular response to redox state	IMP	J:218412
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IMP	J:100158
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IMP	J:158723
Biological Process	GO:0006672	ceramide metabolic process	IMP	J:184361
Biological Process	GO:0006672	ceramide metabolic process	IMP	J:190369
Biological Process	GO:0002063	chondrocyte development	IMP	J:122827
Biological Process	GO:0002063	chondrocyte development	IMP	J:212995
Biological Process	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis	IMP	J:176975
Biological Process	GO:0032963	collagen metabolic process	IMP	J:193344
Biological Process	GO:0097187	dentinogenesis	IMP	J:100158
Biological Process	GO:0071897	DNA biosynthetic process	IMP	J:202378
Biological Process	GO:0090494	dopamine uptake	ISO	J:155856
Biological Process	GO:0001958	endochondral ossification	IMP	J:212995
Biological Process	GO:0001958	endochondral ossification	IMP	J:176975
Biological Process	GO:0001958	endochondral ossification	IMP	J:122827
Biological Process	GO:0085029	extracellular matrix assembly	IMP	J:193344
Biological Process	GO:0070314	G1 to G0 transition	IMP	J:190369
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:202604
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0048286	lung alveolus development	IMP	J:193949
Biological Process	GO:0030324	lung development	IMP	J:193949
Biological Process	GO:0140014	mitotic nuclear division	IMP	J:158723
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IMP	J:213345
Biological Process	GO:0035264	multicellular organism growth	IDA	J:213345
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	IMP	J:184361
Biological Process	GO:0001503	ossification	IMP	J:100158
Biological Process	GO:0001503	ossification	IMP	J:193344
Biological Process	GO:0030072	peptide hormone secretion	IMP	J:97284
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:202378
Biological Process	GO:0015774	polysaccharide transport	IMP	J:184361
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	ISO	J:155856
Biological Process	GO:1903543	positive regulation of exosomal secretion	ISO	J:155856
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IGI	J:202378
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	IMP	J:122383
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:212995
Biological Process	GO:0061035	regulation of cartilage development	IMP	J:212995
Biological Process	GO:1900125	regulation of hyaluronan biosynthetic process	IMP	J:184361
Biological Process	GO:0002685	regulation of leukocyte migration	IMP	J:259461
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:184361
Biological Process	GO:0060541	respiratory system development	IMP	J:193949
Biological Process	GO:0007165	signal transduction	TAS	J:62281
Biological Process	GO:0007165	signal transduction	IMP	J:122383
Biological Process	GO:0001501	skeletal system development	IMP	J:122827
Biological Process	GO:0001501	skeletal system development	IDA	J:213345
Biological Process	GO:0001501	skeletal system development	IMP	J:213345
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	IDA	J:202378
Biological Process	GO:0006665	sphingolipid metabolic process	IMP	J:193949
Biological Process	GO:0006685	sphingomyelin catabolic process	ISO	J:164563
Biological Process	GO:0006685	sphingomyelin catabolic process	IMP	J:204092
Biological Process	GO:0006684	sphingomyelin metabolic process	IDA	J:292528
Biological Process	GO:0006684	sphingomyelin metabolic process	IBA	J:265628
Biological Process	GO:0006684	sphingomyelin metabolic process	IDA	J:62281