GO Annotations Graph

• Symbol: Ptges
• Name: prostaglandin E synthase
• ID: MGI:1927593

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043295	glutathione binding	ISO	J:164563
Molecular Function	GO:0004602	glutathione peroxidase activity	ISO	J:164563
Molecular Function	GO:0004364	glutathione transferase activity	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004667	prostaglandin-D synthase activity	IDA	J:285225
Molecular Function	GO:0004667	prostaglandin-D synthase activity	ISO	J:155856
Molecular Function	GO:0004667	prostaglandin-D synthase activity	TAS	J:77512
Molecular Function	GO:0050220	prostaglandin-E synthase activity	ISO	J:164563
Molecular Function	GO:0050220	prostaglandin-E synthase activity	ISO	J:155856
Molecular Function	GO:0050220	prostaglandin-E synthase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:77512
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005641	nuclear envelope lumen	IDA	J:65167
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Biological Process	GO:0008283	cell population proliferation	IGI	J:136951
Biological Process	GO:0006633	fatty acid biosynthetic process	IEA	J:60000
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:136951
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IMP	J:232433
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0001516	prostaglandin biosynthetic process	IDA	J:285225
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:155856
Biological Process	GO:0001516	prostaglandin biosynthetic process	IBA	J:265628
Biological Process	GO:0006693	prostaglandin metabolic process	IDA	J:65167
Biological Process	GO:0031620	regulation of fever generation	IMP	J:89960
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:90980
Biological Process	GO:0019233	sensory perception of pain	IMP	J:90980