GO Annotations Graph

• Symbol: Sirt3
• Name: sirtuin 3
• ID: MGI:1927665

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008047	enzyme activator activity	IDA	J:176493
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051287	NAD binding	IEA	J:72247
Molecular Function	GO:0070403	NAD+ binding	IBA	J:265628
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:230048
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:276379
Molecular Function	GO:0005515	protein binding	IPI	J:230048
Molecular Function	GO:0005515	protein binding	IPI	J:257325
Molecular Function	GO:0005515	protein binding	IPI	J:174774
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:176493
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:257325
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:65632
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:130436
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	IDA	J:233904
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	IDA	J:257325
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0009060	aerobic respiration	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	IDA	J:129009
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	IMP	J:129009
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0034983	peptidyl-lysine deacetylation	ISO	J:164563
Biological Process	GO:0034983	peptidyl-lysine deacetylation	IDA	J:230048
Biological Process	GO:1902553	positive regulation of catalase activity	ISO	J:164563
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	IDA	J:230048
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:1903109	positive regulation of mitochondrial transcription	IMP	J:257325
Biological Process	GO:1901671	positive regulation of superoxide dismutase activity	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IMP	J:196142