GO Annotations Graph

• Symbol: Ireb2
• Name: iron responsive element binding protein 2
• ID: MGI:1928268

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	ISO	J:155856
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	IBA	J:265628
Molecular Function	GO:0003994	aconitate hydratase activity	IBA	J:265628
Molecular Function	GO:0030350	iron-responsive element binding	ISO	J:155856
Molecular Function	GO:0030350	iron-responsive element binding	ISO	J:164563
Molecular Function	GO:0030350	iron-responsive element binding	IBA	J:265628
Molecular Function	GO:0030350	iron-responsive element binding	IDA	J:87889
Molecular Function	GO:0030350	iron-responsive element binding	IDA	J:87889
Molecular Function	GO:0030350	iron-responsive element binding	IDA	J:66321
Molecular Function	GO:0030350	iron-responsive element binding	IDA	J:87889
Molecular Function	GO:0030350	iron-responsive element binding	IDA	J:87889
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0001069	regulatory region RNA binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0030371	translation repressor activity	TAS	J:67313
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:66321
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:101505
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:73065
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:73065
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:155856
Biological Process	GO:0071283	cellular response to iron(III) ion	ISO	J:155856
Biological Process	GO:0071287	cellular response to manganese ion	ISO	J:155856
Biological Process	GO:0072705	cellular response to mercaptoethanol	ISO	J:155856
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	ISO	J:155856
Biological Process	GO:0006101	citrate metabolic process	IBA	J:265628
Biological Process	GO:0034101	erythrocyte homeostasis	IMP	J:117319
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:131013
Biological Process	GO:0050892	intestinal absorption	IGI	J:131013
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	IGI	J:87889
Biological Process	GO:0006879	intracellular iron ion homeostasis	IGI	J:87889
Biological Process	GO:0006879	intracellular iron ion homeostasis	IDA	J:67313
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:117319
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:87889
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:87889
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:87889
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:87889
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:87889
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IGI	J:176655
Biological Process	GO:0017148	negative regulation of translation	ISO	J:155856
Biological Process	GO:0030316	osteoclast differentiation	IEP	J:146763
Biological Process	GO:0009791	post-embryonic development	IGI	J:131013
Biological Process	GO:0006782	protoporphyrinogen IX biosynthetic process	IMP	J:117319
Biological Process	GO:0010468	regulation of gene expression	IGI	J:131013
Biological Process	GO:0006417	regulation of translation	IMP	J:87889
Biological Process	GO:0006417	regulation of translation	IMP	J:87889
Biological Process	GO:0010041	response to iron(III) ion	ISO	J:155856
Biological Process	GO:0006099	tricarboxylic acid cycle	IBA	J:265628