Mtor GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Mtor
mechanistic target of rapamycin kinase
MGI:1928394

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:93907
Molecular Function	GO:0016301	kinase activity	ISO	J:217701
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:215861
Molecular Function	GO:0005515	protein binding	IPI	J:201730
Molecular Function	GO:0005515	protein binding	IPI	J:161033
Molecular Function	GO:0005515	protein binding	IPI	J:128527
Molecular Function	GO:0005515	protein binding	IPI	J:201730
Molecular Function	GO:0005515	protein binding	IPI	J:164024
Molecular Function	GO:0005515	protein binding	IPI	J:175316
Molecular Function	GO:0005515	protein binding	IPI	J:201589
Molecular Function	GO:0005515	protein binding	IPI	J:139950
Molecular Function	GO:0005515	protein binding	IPI	J:227363
Molecular Function	GO:0005515	protein binding	IPI	J:182033
Molecular Function	GO:0005515	protein binding	IPI	J:167176
Molecular Function	GO:0005515	protein binding	IPI	J:167176
Molecular Function	GO:0005515	protein binding	IPI	J:109360
Molecular Function	GO:0005515	protein binding	IPI	J:278187
Molecular Function	GO:0005515	protein binding	IPI	J:137614
Molecular Function	GO:0005515	protein binding	IPI	J:245269
Molecular Function	GO:0005515	protein binding	IPI	J:111744
Molecular Function	GO:0005515	protein binding	IPI	J:172256
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:175316
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:203811
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:94381
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:136088
Molecular Function	GO:0044877	protein-containing complex binding	IEA	J:72247
Molecular Function	GO:0043022	ribosome binding	IDA	J:167176
Molecular Function	GO:0001002	RNA polymerase III type 1 promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001003	RNA polymerase III type 2 promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001156	TFIIIC-class transcription factor complex binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0045182	translation regulator activity	ISO	J:164563
Molecular Function	GO:0045182	translation regulator activity	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:111744
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:136088
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:201521
Cellular Component	GO:0012505	endomembrane system	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:133330
Cellular Component	GO:0005634	nucleus	IDA	J:136088
Cellular Component	GO:0045335	phagocytic vesicle	ISO	J:164563
Cellular Component	GO:0016605	PML body	IDA	J:111744
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0031931	TORC1 complex	IDA	J:237685
Cellular Component	GO:0031931	TORC1 complex	ISO	J:155856
Cellular Component	GO:0031931	TORC1 complex	ISO	J:164563
Cellular Component	GO:0031931	TORC1 complex	IBA	J:265628
Cellular Component	GO:0031931	TORC1 complex	ISO	J:93907
Cellular Component	GO:0031932	TORC2 complex	ISO	J:164563
Cellular Component	GO:0031932	TORC2 complex	IBA	J:265628
Cellular Component	GO:0031932	TORC2 complex	ISO	J:93907
Biological Process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IDA	J:193963
Biological Process	GO:0048266	behavioral response to pain	IGI	J:304141
Biological Process	GO:0048266	behavioral response to pain	IGI	J:304141
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:136088
Biological Process	GO:0055006	cardiac cell development	IMP	J:195854
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:220106
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:220106
Biological Process	GO:0048738	cardiac muscle tissue development	IMP	J:220106
Biological Process	GO:0030030	cell projection organization	IMP	J:103933
Biological Process	GO:0030030	cell projection organization	ISO	J:103933
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	NAS	J:320285
Biological Process	GO:0071456	cellular response to hypoxia	IDA	J:111744
Biological Process	GO:0071233	cellular response to leucine	ISO	J:164563
Biological Process	GO:1990253	cellular response to leucine starvation	ISO	J:164563
Biological Process	GO:0031669	cellular response to nutrient levels	NAS	J:319972
Biological Process	GO:0031669	cellular response to nutrient levels	NAS	J:319697
Biological Process	GO:0031669	cellular response to nutrient levels	IDA	J:175316
Biological Process	GO:0071470	cellular response to osmotic stress	NAS	J:320285
Biological Process	GO:0009267	cellular response to starvation	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	NAS	J:320275
Biological Process	GO:0006974	DNA damage response	NAS	J:320285
Biological Process	GO:0006112	energy reserve metabolic process	IMP	J:220106
Biological Process	GO:0007281	germ cell development	IDA	J:78328
Biological Process	GO:0003007	heart morphogenesis	IMP	J:220106
Biological Process	GO:0003179	heart valve morphogenesis	IMP	J:220106
Biological Process	GO:0006954	inflammatory response	IGI	J:304141
Biological Process	GO:0006954	inflammatory response	IGI	J:304141
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0016236	macroautophagy	IMP	J:114863
Biological Process	GO:0060135	maternal process involved in female pregnancy	ISO	J:155856
Biological Process	GO:0048255	mRNA stabilization	ISO	J:155856
Biological Process	GO:0035264	multicellular organism growth	IMP	J:220106
Biological Process	GO:0043066	negative regulation of apoptotic process	NAS	J:319697
Biological Process	GO:0010507	negative regulation of autophagy	NAS	J:320286
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:155856
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:175316
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:136088
Biological Process	GO:0045792	negative regulation of cell size	IGI	J:103933
Biological Process	GO:0045792	negative regulation of cell size	IGI	J:104911
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:103933
Biological Process	GO:1904193	negative regulation of cholangiocyte apoptotic process	ISO	J:155856
Biological Process	GO:1904213	negative regulation of iodide transmembrane transport	ISO	J:155856
Biological Process	GO:0016242	negative regulation of macroautophagy	IBA	J:265628
Biological Process	GO:0016242	negative regulation of macroautophagy	IMP	J:208584
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:217701
Biological Process	GO:0016242	negative regulation of macroautophagy	IMP	J:114863
Biological Process	GO:0014736	negative regulation of muscle atrophy	ISO	J:155856
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IGI	J:304141
Biological Process	GO:0051647	nucleus localization	ISO	J:164563
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:217386
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:203811
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:136088
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:94381
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	ISO	J:217701
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:93907
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IDA	J:93907
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	NAS	J:319697
Biological Process	GO:0030307	positive regulation of cell growth	NAS	J:319682
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:2000774	positive regulation of cellular senescence	ISO	J:155856
Biological Process	GO:1904056	positive regulation of cholangiocyte proliferation	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:1904000	positive regulation of eating behavior	ISO	J:155856
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0045821	positive regulation of glycolytic process	NAS	J:163259
Biological Process	GO:1904197	positive regulation of granulosa cell proliferation	ISO	J:155856
Biological Process	GO:0051549	positive regulation of keratinocyte migration	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	IDA	J:93907
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	ISO	J:164563
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	NAS	J:163259
Biological Process	GO:0010831	positive regulation of myotube differentiation	IGI	J:153992
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0014042	positive regulation of neuron maturation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IMP	J:217386
Biological Process	GO:1905857	positive regulation of pentose-phosphate shunt	NAS	J:163259
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:93907
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:285299
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:220106
Biological Process	GO:1904058	positive regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:1904206	positive regulation of skeletal muscle hypertrophy	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	IDA	J:93907
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III	ISO	J:164563
Biological Process	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0045948	positive regulation of translational initiation	ISO	J:164563
Biological Process	GO:1903691	positive regulation of wound healing, spreading of epidermal cells	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IMP	J:220106
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:93907
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	ISO	J:93907
Biological Process	GO:0006468	protein phosphorylation	ISO	J:285299
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	IDA	J:203811
Biological Process	GO:0090335	regulation of brown fat cell differentiation	ISO	J:155856
Biological Process	GO:0006109	regulation of carbohydrate metabolic process	ISO	J:155856
Biological Process	GO:0043610	regulation of carbohydrate utilization	ISO	J:155856
Biological Process	GO:0001558	regulation of cell growth	ISO	J:164563
Biological Process	GO:0008361	regulation of cell size	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:263234
Biological Process	GO:0031998	regulation of fatty acid beta-oxidation	ISO	J:155856
Biological Process	GO:0005979	regulation of glycogen biosynthetic process	ISO	J:155856
Biological Process	GO:0043087	regulation of GTPase activity	IMP	J:93907
Biological Process	GO:1904059	regulation of locomotor rhythm	IMP	J:263234
Biological Process	GO:0090559	regulation of membrane permeability	IMP	J:220106
Biological Process	GO:0031641	regulation of myelination	IMP	J:201967
Biological Process	GO:0045670	regulation of osteoclast differentiation	IDA	J:150006
Biological Process	GO:0045859	regulation of protein kinase activity	IGI	J:104911
Biological Process	GO:0051896	regulation of protein kinase B signaling	IMP	J:220106
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:141655
Biological Process	GO:0032095	regulation of response to food	ISO	J:155856
Biological Process	GO:0099547	regulation of translation at synapse, modulating synaptic transmission	ISO	J:155856
Biological Process	GO:0043200	response to amino acid	ISO	J:164563
Biological Process	GO:0043200	response to amino acid	IDA	J:93907
Biological Process	GO:0042220	response to cocaine	ISO	J:155856
Biological Process	GO:0009408	response to heat	IGI	J:304141
Biological Process	GO:0009408	response to heat	IGI	J:304141
Biological Process	GO:0032868	response to insulin	IDA	J:93907
Biological Process	GO:0043278	response to morphine	ISO	J:155856
Biological Process	GO:0007584	response to nutrient	ISO	J:164563
Biological Process	GO:0031667	response to nutrient levels	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0031529	ruffle organization	IDA	J:93907
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0021510	spinal cord development	ISO	J:155856
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	IMP	J:233777
Biological Process	GO:0031929	TOR signaling	IGI	J:239192
Biological Process	GO:0031929	TOR signaling	ISO	J:164563
Biological Process	GO:0031929	TOR signaling	IBA	J:265628
Biological Process	GO:0038202	TORC1 signaling	ISO	J:164563
Biological Process	GO:0038202	TORC1 signaling	ISO	J:285299
Biological Process	GO:0038203	TORC2 signaling	ISO	J:285299
Biological Process	GO:0008542	visual learning	ISO	J:155856
Biological Process	GO:0050882	voluntary musculoskeletal movement	IMP	J:220106

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24