Mtor GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Mtor
mechanistic target of rapamycin kinase
MGI:1928394

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:93907
Molecular Function	GO:0016301	kinase activity	ISO	J:217701
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:215861
Molecular Function	GO:0005515	protein binding	IPI	J:201730
Molecular Function	GO:0005515	protein binding	IPI	J:161033
Molecular Function	GO:0005515	protein binding	IPI	J:128527
Molecular Function	GO:0005515	protein binding	IPI	J:201730
Molecular Function	GO:0005515	protein binding	IPI	J:164024
Molecular Function	GO:0005515	protein binding	IPI	J:175316
Molecular Function	GO:0005515	protein binding	IPI	J:201589
Molecular Function	GO:0005515	protein binding	IPI	J:139950
Molecular Function	GO:0005515	protein binding	IPI	J:227363
Molecular Function	GO:0005515	protein binding	IPI	J:182033
Molecular Function	GO:0005515	protein binding	IPI	J:167176
Molecular Function	GO:0005515	protein binding	IPI	J:167176
Molecular Function	GO:0005515	protein binding	IPI	J:109360
Molecular Function	GO:0005515	protein binding	IPI	J:278187
Molecular Function	GO:0005515	protein binding	IPI	J:137614
Molecular Function	GO:0005515	protein binding	IPI	J:245269
Molecular Function	GO:0005515	protein binding	IPI	J:111744
Molecular Function	GO:0005515	protein binding	IPI	J:172256
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:175316
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:203811
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:94381
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:136088
Molecular Function	GO:0044877	protein-containing complex binding	IEA	J:72247
Molecular Function	GO:0043022	ribosome binding	IDA	J:167176
Molecular Function	GO:0001002	RNA polymerase III type 1 promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001003	RNA polymerase III type 2 promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001156	TFIIIC-class transcription factor complex binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0045182	translation regulator activity	ISO	J:164563
Molecular Function	GO:0045182	translation regulator activity	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:111744
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:136088
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:201521
Cellular Component	GO:0012505	endomembrane system	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:133330
Cellular Component	GO:0005634	nucleus	IDA	J:136088
Cellular Component	GO:0045335	phagocytic vesicle	ISO	J:164563
Cellular Component	GO:0016605	PML body	IDA	J:111744
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0031931	TORC1 complex	IDA	J:237685
Cellular Component	GO:0031931	TORC1 complex	ISO	J:155856
Cellular Component	GO:0031931	TORC1 complex	ISO	J:164563
Cellular Component	GO:0031931	TORC1 complex	IBA	J:265628
Cellular Component	GO:0031931	TORC1 complex	ISO	J:93907
Cellular Component	GO:0031932	TORC2 complex	ISO	J:164563
Cellular Component	GO:0031932	TORC2 complex	IBA	J:265628
Cellular Component	GO:0031932	TORC2 complex	ISO	J:93907
Biological Process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IDA	J:193963
Biological Process	GO:0048266	behavioral response to pain	IGI	J:304141
Biological Process	GO:0048266	behavioral response to pain	IGI	J:304141
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:136088
Biological Process	GO:0055006	cardiac cell development	IMP	J:195854
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:220106
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:220106
Biological Process	GO:0048738	cardiac muscle tissue development	IMP	J:220106
Biological Process	GO:0030030	cell projection organization	IMP	J:103933
Biological Process	GO:0030030	cell projection organization	ISO	J:103933
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	NAS	J:320285
Biological Process	GO:0071456	cellular response to hypoxia	IDA	J:111744
Biological Process	GO:0071233	cellular response to leucine	ISO	J:164563
Biological Process	GO:1990253	cellular response to leucine starvation	ISO	J:164563
Biological Process	GO:0031669	cellular response to nutrient levels	NAS	J:319972
Biological Process	GO:0031669	cellular response to nutrient levels	NAS	J:319697
Biological Process	GO:0031669	cellular response to nutrient levels	IDA	J:175316
Biological Process	GO:0071470	cellular response to osmotic stress	NAS	J:320285
Biological Process	GO:0009267	cellular response to starvation	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	NAS	J:320275
Biological Process	GO:0006974	DNA damage response	NAS	J:320285
Biological Process	GO:0006112	energy reserve metabolic process	IMP	J:220106
Biological Process	GO:0007281	germ cell development	IDA	J:78328
Biological Process	GO:0003007	heart morphogenesis	IMP	J:220106
Biological Process	GO:0003179	heart valve morphogenesis	IMP	J:220106
Biological Process	GO:0006954	inflammatory response	IGI	J:304141
Biological Process	GO:0006954	inflammatory response	IGI	J:304141
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0016236	macroautophagy	IMP	J:114863
Biological Process	GO:0060135	maternal process involved in female pregnancy	ISO	J:155856
Biological Process	GO:0048255	mRNA stabilization	ISO	J:155856
Biological Process	GO:0035264	multicellular organism growth	IMP	J:220106
Biological Process	GO:0043066	negative regulation of apoptotic process	NAS	J:319697
Biological Process	GO:0010507	negative regulation of autophagy	NAS	J:320286
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:155856
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:175316
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:136088
Biological Process	GO:0045792	negative regulation of cell size	IGI	J:103933
Biological Process	GO:0045792	negative regulation of cell size	IGI	J:104911
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:103933
Biological Process	GO:1904193	negative regulation of cholangiocyte apoptotic process	ISO	J:155856
Biological Process	GO:1904213	negative regulation of iodide transmembrane transport	ISO	J:155856
Biological Process	GO:0016242	negative regulation of macroautophagy	IBA	J:265628
Biological Process	GO:0016242	negative regulation of macroautophagy	IMP	J:208584
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:217701
Biological Process	GO:0016242	negative regulation of macroautophagy	IMP	J:114863
Biological Process	GO:0014736	negative regulation of muscle atrophy	ISO	J:155856
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IGI	J:304141
Biological Process	GO:0051647	nucleus localization	ISO	J:164563
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:217386
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:203811
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:136088
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:94381
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	ISO	J:217701
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:93907
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IDA	J:93907
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	NAS	J:319697
Biological Process	GO:0030307	positive regulation of cell growth	NAS	J:319682
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:2000774	positive regulation of cellular senescence	ISO	J:155856
Biological Process	GO:1904056	positive regulation of cholangiocyte proliferation	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:1904000	positive regulation of eating behavior	ISO	J:155856
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0045821	positive regulation of glycolytic process	NAS	J:163259
Biological Process	GO:1904197	positive regulation of granulosa cell proliferation	ISO	J:155856
Biological Process	GO:0051549	positive regulation of keratinocyte migration	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	IDA	J:93907
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	ISO	J:164563
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	NAS	J:163259
Biological Process	GO:0010831	positive regulation of myotube differentiation	IGI	J:153992
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0014042	positive regulation of neuron maturation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IMP	J:217386
Biological Process	GO:1905857	positive regulation of pentose-phosphate shunt	NAS	J:163259
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:93907
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:285299
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:220106
Biological Process	GO:1904058	positive regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:1904206	positive regulation of skeletal muscle hypertrophy	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	IDA	J:93907
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III	ISO	J:164563
Biological Process	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0045948	positive regulation of translational initiation	ISO	J:164563
Biological Process	GO:1903691	positive regulation of wound healing, spreading of epidermal cells	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IMP	J:220106
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:93907
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	ISO	J:93907
Biological Process	GO:0006468	protein phosphorylation	ISO	J:285299
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	IDA	J:203811
Biological Process	GO:0090335	regulation of brown fat cell differentiation	ISO	J:155856
Biological Process	GO:0006109	regulation of carbohydrate metabolic process	ISO	J:155856
Biological Process	GO:0043610	regulation of carbohydrate utilization	ISO	J:155856
Biological Process	GO:0001558	regulation of cell growth	ISO	J:164563
Biological Process	GO:0008361	regulation of cell size	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:263234
Biological Process	GO:0031998	regulation of fatty acid beta-oxidation	ISO	J:155856
Biological Process	GO:0005979	regulation of glycogen biosynthetic process	ISO	J:155856
Biological Process	GO:0043087	regulation of GTPase activity	IMP	J:93907
Biological Process	GO:1904059	regulation of locomotor rhythm	IMP	J:263234
Biological Process	GO:0090559	regulation of membrane permeability	IMP	J:220106
Biological Process	GO:0031641	regulation of myelination	IMP	J:201967
Biological Process	GO:0045670	regulation of osteoclast differentiation	IDA	J:150006
Biological Process	GO:0045859	regulation of protein kinase activity	IGI	J:104911
Biological Process	GO:0051896	regulation of protein kinase B signaling	IMP	J:220106
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:141655
Biological Process	GO:0032095	regulation of response to food	ISO	J:155856
Biological Process	GO:0099547	regulation of translation at synapse, modulating synaptic transmission	ISO	J:155856
Biological Process	GO:0043200	response to amino acid	ISO	J:164563
Biological Process	GO:0043200	response to amino acid	IDA	J:93907
Biological Process	GO:0042220	response to cocaine	ISO	J:155856
Biological Process	GO:0009408	response to heat	IGI	J:304141
Biological Process	GO:0009408	response to heat	IGI	J:304141
Biological Process	GO:0032868	response to insulin	IDA	J:93907
Biological Process	GO:0043278	response to morphine	ISO	J:155856
Biological Process	GO:0007584	response to nutrient	ISO	J:164563
Biological Process	GO:0031667	response to nutrient levels	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0031529	ruffle organization	IDA	J:93907
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0021510	spinal cord development	ISO	J:155856
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	IMP	J:233777
Biological Process	GO:0031929	TOR signaling	IGI	J:239192
Biological Process	GO:0031929	TOR signaling	ISO	J:164563
Biological Process	GO:0031929	TOR signaling	IBA	J:265628
Biological Process	GO:0038202	TORC1 signaling	ISO	J:164563
Biological Process	GO:0038202	TORC1 signaling	ISO	J:285299
Biological Process	GO:0038203	TORC2 signaling	ISO	J:285299
Biological Process	GO:0008542	visual learning	ISO	J:155856
Biological Process	GO:0050882	voluntary musculoskeletal movement	IMP	J:220106

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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