GO Annotations Graph

• Symbol: Scube2
• Name: signal peptide, CUB domain, EGF-like 2
• ID: MGI:1928765

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0097108	hedgehog family protein binding	IPI	J:226676
Molecular Function	GO:0042802	identical protein binding	ISO	J:73065
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:226676
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:226676
Cellular Component	GO:0005615	extracellular space	ISA	J:73065
Cellular Component	GO:0019897	extrinsic component of plasma membrane	ISO	J:73065
Biological Process	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	IMP	J:226676
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	IMP	J:226676
Biological Process	GO:0045778	positive regulation of ossification	IMP	J:226676
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:226676
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:226676
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:226676
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA	J:226676
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	IDA	J:226676
Biological Process	GO:0007165	signal transduction	IBA	J:265628