GO Annotations Graph

• Symbol: Rnf8
• Name: ring finger protein 8
• ID: MGI:1929069

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	IMP	J:145559
Molecular Function	GO:0042393	histone binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:242565
Molecular Function	GO:0005515	protein binding	IPI	J:245385
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IMP	J:145559
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IMP	J:145559
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:176962
Cellular Component	GO:0005737	cytoplasm	IDA	J:242565
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:242565
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	IBA	J:265628
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0000151	ubiquitin ligase complex	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IDA	J:176962
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IBA	J:265628
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:192582
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:176962
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0070535	histone H2A K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070535	histone H2A K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0033522	histone H2A ubiquitination	ISO	J:164563
Biological Process	GO:0045190	isotype switching	IMP	J:156522
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045739	positive regulation of DNA repair	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	IBA	J:265628
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IEA	J:72247
Biological Process	GO:0010212	response to ionizing radiation	ISO	J:164563
Biological Process	GO:0042770	signal transduction in response to DNA damage	IMP	J:145559
Biological Process	GO:0035092	sperm DNA condensation	IMP	J:242565
Biological Process	GO:0035092	sperm DNA condensation	IMP	J:159114
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IBA	J:265628