GO Annotations Graph

• Symbol: Cldn18
• Name: claudin 18
• ID: MGI:1929209

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:196719
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Cellular Component	GO:0005923	bicellular tight junction	IBA	J:265628
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0070160	tight junction	IDA	J:292389
Biological Process	GO:0070830	bicellular tight junction assembly	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0048565	digestive tract development	IMP	J:196719
Biological Process	GO:0045779	negative regulation of bone resorption	IMP	J:196719
Biological Process	GO:2001205	negative regulation of osteoclast development	IMP	J:196719
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	IDA	J:196719
Biological Process	GO:0034504	protein localization to nucleus	IDA	J:196719
Biological Process	GO:0120192	tight junction assembly	IMP	J:292389
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	IMP	J:196719