GO Annotations Graph

• Symbol: Rabgef1
• Name: RAB guanine nucleotide exchange factor (GEF) 1
• ID: MGI:1929459

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:172908
Molecular Function	GO:0005515	protein binding	IPI	J:145419
Molecular Function	GO:0005515	protein binding	IPI	J:91790
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:145419
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0030425	dendrite	IPI	J:326501
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	IBA	J:265628
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0031982	vesicle	IDA	J:145419
Biological Process	GO:0098935	dendritic transport	IPI	J:326501
Biological Process	GO:0098935	dendritic transport	IMP	J:326501
Biological Process	GO:0098935	dendritic transport	IDA	J:326501
Biological Process	GO:0098935	dendritic transport	IDA	J:326501
Biological Process	GO:0098935	dendritic transport	IPI	J:326501
Biological Process	GO:0098935	dendritic transport	IPI	J:326501
Biological Process	GO:0098935	dendritic transport	IMP	J:326501
Biological Process	GO:0098935	dendritic transport	IDA	J:326501
Biological Process	GO:0098935	dendritic transport	IMP	J:326501
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:107183
Biological Process	GO:0032635	interleukin-6 production	IMP	J:107183
Biological Process	GO:0038109	Kit signaling pathway	IMP	J:107183
Biological Process	GO:0032762	mast cell cytokine production	IMP	J:107183
Biological Process	GO:0043303	mast cell degranulation	IMP	J:91790
Biological Process	GO:0097531	mast cell migration	IMP	J:107183
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:91790
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:107183
Biological Process	GO:1900235	negative regulation of Kit signaling pathway	IMP	J:107183
Biological Process	GO:0002686	negative regulation of leukocyte migration	IMP	J:107183
Biological Process	GO:0033004	negative regulation of mast cell activation	IMP	J:91790
Biological Process	GO:0032764	negative regulation of mast cell cytokine production	IMP	J:107183
Biological Process	GO:0043305	negative regulation of mast cell degranulation	IMP	J:91790
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:107183
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IMP	J:91790
Biological Process	GO:0048261	negative regulation of receptor-mediated endocytosis	IMP	J:107183
Biological Process	GO:0006468	protein phosphorylation	IMP	J:107183
Biological Process	GO:0006612	protein targeting to membrane	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0007265	Ras protein signal transduction	IMP	J:91790
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:107183
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	IDA	J:145419
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	IMP	J:91790
Biological Process	GO:0016192	vesicle-mediated transport	IEA	J:72247