GO Annotations Graph

• Symbol: Tyk2
• Name: tyrosine kinase 2
• ID: MGI:1929470

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005126	cytokine receptor binding	IBA	J:265628
Molecular Function	GO:0005131	growth hormone receptor binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8950034
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8950442
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8950612
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8950679
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006466
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676072
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705471
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707972
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707979
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0042022	interleukin-12 receptor complex	NAS	J:37050
Cellular Component	GO:0072536	interleukin-23 receptor complex	NAS	J:76845
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IGI	J:97143
Biological Process	GO:0008283	cell population proliferation	IGI	J:97143
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	NAS	J:319975
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0032740	positive regulation of interleukin-17 production	NAS	J:320271
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	NAS	J:319975
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:65966
Biological Process	GO:2000318	positive regulation of T-helper 17 type immune response	NAS	J:320271
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	ISO	J:164563