GO Annotations Graph

• Symbol: Ikbke
• Name: inhibitor of kappaB kinase epsilon
• ID: MGI:1929612

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008384	IkappaB kinase activity	IDA	J:66314
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	IDA	J:222665
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004704	NF-kappaB-inducing kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:176466
Molecular Function	GO:0004672	protein kinase activity	IDA	J:176466
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:222665
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0016605	PML body	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IDA	J:222665
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0010467	gene expression	IMP	J:176466
Biological Process	GO:0007252	I-kappaB phosphorylation	IDA	J:66314
Biological Process	GO:0006955	immune response	IMP	J:176466
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IDA	J:176466
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:0048255	mRNA stabilization	IMP	J:176466
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:176466
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010884	positive regulation of lipid storage	IMP	J:202115
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	IMP	J:235021
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0043254	regulation of protein-containing complex assembly	IMP	J:176466
Biological Process	GO:0035456	response to interferon-beta	ISO	J:164563
Biological Process	GO:0034340	response to type I interferon	IDA	J:222665