GO Annotations Graph

• Symbol: Tbk1
• Name: TANK-binding kinase 1
• ID: MGI:1929658

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:245392
Molecular Function	GO:0042802	identical protein binding	IPI	J:245352
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	IDA	J:145965
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:245352
Molecular Function	GO:0005515	protein binding	IPI	J:166835
Molecular Function	GO:0005515	protein binding	IPI	J:209896
Molecular Function	GO:0005515	protein binding	IPI	J:236952
Molecular Function	GO:0005515	protein binding	IPI	J:66310
Molecular Function	GO:0005515	protein binding	IPI	J:183537
Molecular Function	GO:0005515	protein binding	IPI	J:177502
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:200472
Molecular Function	GO:0005515	protein binding	IPI	J:200396
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:126125
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:222675
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1810458
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1810473
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	IMP	J:96405
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:96405
Biological Process	GO:0051607	defense response to virus	IEA	J:60000
Biological Process	GO:0044565	dendritic cell proliferation	IGI	J:204786
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0032608	interferon-beta production	IMP	J:96405
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:161102
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:222675
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:96405
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:280922
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	IMP	J:235021
Biological Process	GO:1904417	positive regulation of xenophagy	IMP	J:222675
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0031323	regulation of cellular metabolic process	IGI	J:239522
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0032479	regulation of type I interferon production	ISO	J:164563