GO Annotations Graph

• Symbol: Cacna2d2
• Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
• ID: MGI:1929813

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:70845
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9659489
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IBA	J:265628
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IDA	J:70845
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	IC	J:70845
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0055001	muscle cell development	IMP	J:121463
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:121463
Biological Process	GO:0035265	organ growth	IMP	J:43719
Biological Process	GO:0035265	organ growth	IMP	J:43719
Biological Process	GO:0046622	positive regulation of organ growth	IMP	J:43719
Biological Process	GO:0008016	regulation of heart contraction	ISO	J:155856
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:121463
Biological Process	GO:0060024	rhythmic synaptic transmission	IMP	J:107094