GO Annotations Graph

• Symbol: Akr1a1
• Name: aldo-keto reductase family 1, member A1
• ID: MGI:1929955

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008106	alcohol dehydrogenase (NADP+) activity	NAS	J:63126
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IBA	J:265628
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISS	J:63126
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IDA	J:87286
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	TAS	J:63126
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IDA	J:100379
Molecular Function	GO:0047655	allyl-alcohol dehydrogenase activity	IEA	J:72245
Molecular Function	GO:0047941	glucuronolactone reductase activity	ISO	J:155856
Molecular Function	GO:0047941	glucuronolactone reductase activity	ISO	J:164563
Molecular Function	GO:0047941	glucuronolactone reductase activity	IDA	J:188043
Molecular Function	GO:0047939	L-glucuronate reductase activity	ISO	J:155856
Molecular Function	GO:0047939	L-glucuronate reductase activity	ISO	J:164563
Molecular Function	GO:0047939	L-glucuronate reductase activity	IDA	J:100379
Molecular Function	GO:0047939	L-glucuronate reductase activity	IMP	J:164548
Molecular Function	GO:0047939	L-glucuronate reductase activity	IDA	J:100379
Molecular Function	GO:0019726	mevaldate reductase (NADPH) activity	IEA	J:72245
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	IMP	J:282972
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:100379
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:100379
Cellular Component	GO:0005829	cytosol	IDA	J:323240
Cellular Component	GO:0005829	cytosol	IDA	J:100379
Cellular Component	GO:0005829	cytosol	IDA	J:100379
Cellular Component	GO:0005829	cytosol	IDA	J:100379
Cellular Component	GO:0005829	cytosol	IDA	J:100379
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0045202	synapse	EXP	J:182391
Cellular Component	GO:0045202	synapse	IDA	J:182391
Biological Process	GO:0046185	aldehyde catabolic process	IDA	J:100379
Biological Process	GO:0110095	cellular detoxification of aldehyde	IMP	J:188043
Biological Process	GO:0110095	cellular detoxification of aldehyde	ISO	J:155856
Biological Process	GO:0042840	D-glucuronate catabolic process	ISO	J:155856
Biological Process	GO:0042840	D-glucuronate catabolic process	IDA	J:100379
Biological Process	GO:0044597	daunorubicin metabolic process	ISO	J:164563
Biological Process	GO:0044598	doxorubicin metabolic process	ISO	J:164563
Biological Process	GO:0019640	glucuronate catabolic process to xylulose 5-phosphate	IDA	J:323240
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	ISO	J:155856
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	IMP	J:164548
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	IDA	J:100379
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000