GO Annotations Graph

• Symbol: Ghrl
• Name: ghrelin
• ID: MGI:1930008

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:155856
Molecular Function	GO:0031768	ghrelin receptor binding	ISO	J:155856
Molecular Function	GO:0031768	ghrelin receptor binding	IBA	J:265628
Molecular Function	GO:0016608	growth hormone-releasing hormone activity	ISO	J:155856
Molecular Function	GO:0016608	growth hormone-releasing hormone activity	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	TAS	J:63705
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:63705
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IDA	J:63705
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Biological Process	GO:0008154	actin polymerization or depolymerization	ISO	J:164563
Biological Process	GO:0008343	adult feeding behavior	IDA	J:104704
Biological Process	GO:0046697	decidualization	ISO	J:164563
Biological Process	GO:0016358	dendrite development	ISO	J:73065
Biological Process	GO:0016358	dendrite development	IMP	J:107095
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:107095
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001696	gastric acid secretion	ISO	J:155856
Biological Process	GO:0001696	gastric acid secretion	IBA	J:265628
Biological Process	GO:0035483	gastric emptying	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:121019
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:121019
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0040013	negative regulation of locomotion	IMP	J:104703
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:1904179	positive regulation of adipose tissue development	ISO	J:155856
Biological Process	GO:0032100	positive regulation of appetite	IDA	J:104704
Biological Process	GO:0032100	positive regulation of appetite	IDA	J:89243
Biological Process	GO:0032100	positive regulation of appetite	IGI	J:89243
Biological Process	GO:0032100	positive regulation of appetite	IMP	J:117370
Biological Process	GO:1903012	positive regulation of bone development	ISO	J:155856
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO	J:164563
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:151960
Biological Process	GO:0051461	positive regulation of corticotropin secretion	ISO	J:164563
Biological Process	GO:0051464	positive regulation of cortisol secretion	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1904000	positive regulation of eating behavior	ISO	J:155856
Biological Process	GO:2000253	positive regulation of feeding behavior	ISO	J:155856
Biological Process	GO:1904346	positive regulation of gastric mucosal blood circulation	ISO	J:155856
Biological Process	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	ISO	J:155856
Biological Process	GO:0045927	positive regulation of growth	ISO	J:155856
Biological Process	GO:0060124	positive regulation of growth hormone secretion	ISO	J:155856
Biological Process	GO:0060124	positive regulation of growth hormone secretion	ISO	J:164563
Biological Process	GO:0060124	positive regulation of growth hormone secretion	IBA	J:265628
Biological Process	GO:0040010	positive regulation of growth rate	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0032097	positive regulation of response to food	ISO	J:155856
Biological Process	GO:0120058	positive regulation of small intestinal transit	ISO	J:155856
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	ISO	J:155856
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:155856
Biological Process	GO:0051965	positive regulation of synapse assembly	IMP	J:107095
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:73065
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1905333	regulation of gastric motility	ISO	J:155856
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0032095	regulation of response to food	ISO	J:155856
Biological Process	GO:0032095	regulation of response to food	IBA	J:265628
Biological Process	GO:0051969	regulation of transmission of nerve impulse	ISO	J:155856
Biological Process	GO:0043627	response to estrogen	ISO	J:164563
Biological Process	GO:0009725	response to hormone	ISO	J:164563
Biological Process	GO:0007416	synapse assembly	IMP	J:107095
Biological Process	GO:0007416	synapse assembly	IMP	J:107095
Biological Process	GO:0008542	visual learning	ISO	J:73065