GO Annotations Graph

• Symbol: Piwil2
• Name: piwi-like RNA-mediated gene silencing 2
• ID: MGI:1930036

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003729	mRNA binding	IDA	J:147897
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0034584	piRNA binding	IDA	J:141096
Molecular Function	GO:0034584	piRNA binding	ISO	J:164563
Molecular Function	GO:0034584	piRNA binding	IDA	J:133343
Molecular Function	GO:0034584	piRNA binding	IDA	J:135163
Molecular Function	GO:0034584	piRNA binding	IDA	J:148065
Molecular Function	GO:0034584	piRNA binding	IDA	J:121322
Molecular Function	GO:0034584	piRNA binding	IBA	J:265628
Molecular Function	GO:1905538	polysome binding	IDA	J:147897
Molecular Function	GO:0005515	protein binding	IPI	J:161124
Molecular Function	GO:0005515	protein binding	IPI	J:272534
Molecular Function	GO:0005515	protein binding	IPI	J:147897
Molecular Function	GO:0005515	protein binding	IPI	J:239197
Molecular Function	GO:0005515	protein binding	IPI	J:288732
Molecular Function	GO:0005515	protein binding	IPI	J:152108
Molecular Function	GO:0005515	protein binding	IPI	J:148942
Molecular Function	GO:0005515	protein binding	IPI	J:161125
Molecular Function	GO:0005515	protein binding	IPI	J:243444
Molecular Function	GO:0005515	protein binding	IPI	J:112036
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:243488
Molecular Function	GO:0004521	RNA endonuclease activity	IMP	J:184034
Molecular Function	GO:0004521	RNA endonuclease activity	IMP	J:199259
Molecular Function	GO:0004521	RNA endonuclease activity	IBA	J:265628
Cellular Component	GO:0033391	chromatoid body	IDA	J:147897
Cellular Component	GO:0033391	chromatoid body	IDA	J:173639
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:288732
Cellular Component	GO:0005737	cytoplasm	IDA	J:147897
Cellular Component	GO:0005737	cytoplasm	IDA	J:156954
Cellular Component	GO:0005737	cytoplasm	IDA	J:173639
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5605205
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5605213
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5605279
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5605349
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5606226
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5606252
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5629217
Cellular Component	GO:0097433	dense body	IDA	J:173639
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:237199
Cellular Component	GO:0043186	P granule	IDA	J:159518
Cellular Component	GO:0043186	P granule	IDA	J:141096
Cellular Component	GO:0043186	P granule	IBA	J:265628
Cellular Component	GO:0010370	perinucleolar chromocenter	IDA	J:173639
Cellular Component	GO:1990923	PET complex	IDA	J:229314
Cellular Component	GO:0071546	pi-body	IDA	J:155865
Cellular Component	GO:0071546	pi-body	IDA	J:156018
Cellular Component	GO:0071546	pi-body	IDA	J:152071
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0043046	DNA methylation involved in gamete generation	IMP	J:141096
Biological Process	GO:0043046	DNA methylation involved in gamete generation	IMP	J:133343
Biological Process	GO:0030718	germ-line stem cell population maintenance	IMP	J:147897
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042754	negative regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0042754	negative regulation of circadian rhythm	IMP	J:272534
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:184034
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:199259
Biological Process	GO:0048477	oogenesis	IEP	J:135163
Biological Process	GO:0000239	pachytene	IMP	J:173639
Biological Process	GO:0000239	pachytene	IGI	J:173639
Biological Process	GO:0034587	piRNA processing	IMP	J:133343
Biological Process	GO:0034587	piRNA processing	IDA	J:121322
Biological Process	GO:0034587	piRNA processing	IDA	J:229314
Biological Process	GO:0034587	piRNA processing	IDA	J:243488
Biological Process	GO:0034587	piRNA processing	IMP	J:184034
Biological Process	GO:0034587	piRNA processing	IMP	J:199259
Biological Process	GO:0034587	piRNA processing	IDA	J:141096
Biological Process	GO:0034587	piRNA processing	IDA	J:148065
Biological Process	GO:0060903	positive regulation of meiosis I	IMP	J:87735
Biological Process	GO:0045727	positive regulation of translation	IMP	J:147897
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0000966	RNA 5'-end processing	IDA	J:121322
Biological Process	GO:0031047	RNA-mediated gene silencing	IMP	J:141096
Biological Process	GO:0031047	RNA-mediated gene silencing	IMP	J:133343
Biological Process	GO:0031047	RNA-mediated gene silencing	IMP	J:121322
Biological Process	GO:0031047	RNA-mediated gene silencing	IBA	J:265628
Biological Process	GO:0007283	spermatogenesis	IMP	J:199259
Biological Process	GO:0007283	spermatogenesis	IMP	J:184034
Biological Process	GO:0007283	spermatogenesis	IMP	J:133343