GO Annotations Graph

• Symbol: Clcf1
• Name: cardiotrophin-like cytokine factor 1
• ID: MGI:1930088

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	ISO	J:164563
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	ISO	J:164563
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	TAS	J:85998
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:57927
Molecular Function	GO:0005515	protein binding	IPI	J:211242
Molecular Function	GO:0005515	protein binding	IPI	J:287730
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0097059	CNTFR-CLCF1 complex	ISO	J:164563
Cellular Component	GO:0097059	CNTFR-CLCF1 complex	IBA	J:265628
Cellular Component	GO:0097058	CRLF-CLCF1 complex	ISO	J:164563
Cellular Component	GO:0097058	CRLF-CLCF1 complex	TAS	J:85998
Cellular Component	GO:0097058	CRLF-CLCF1 complex	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Biological Process	GO:0030183	B cell differentiation	IDA	J:57927
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:57927
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	NAS	J:85998
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	NAS	J:85998
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IDA	J:172893
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:133136
Biological Process	GO:0030890	positive regulation of B cell proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	TAS	J:173002
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IDA	J:133136
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	IDA	J:133136
Biological Process	GO:0002830	positive regulation of type 2 immune response	NAS	J:133136
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:172893
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IDA	J:57927
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	TAS	J:173002
Biological Process	GO:0050727	regulation of inflammatory response	NAS	J:57927
Biological Process	GO:0051896	regulation of protein kinase B signaling	TAS	J:173002
Biological Process	GO:0007165	signal transduction	IDA	J:57927