GO Annotations Graph

• Symbol: Ern1
• Name: endoplasmic reticulum to nucleus signalling 1
• ID: MGI:1930134

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0004519	endonuclease activity	IDA	J:107824
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:155856
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:201886
Molecular Function	GO:0005515	protein binding	IPI	J:147348
Molecular Function	GO:0005515	protein binding	IPI	J:145150
Molecular Function	GO:0005515	protein binding	IPI	J:136554
Molecular Function	GO:0005515	protein binding	IPI	J:136554
Molecular Function	GO:0005515	protein binding	IPI	J:200442
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:255334
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:255334
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004521	RNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0004521	RNA endonuclease activity	IBA	J:265628
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:255334
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:95320
Molecular Function	GO:0004540	RNA nuclease activity	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0045182	translation regulator activity	TAS	J:171795
Molecular Function	GO:0051082	unfolded protein binding	IBA	J:265628
Cellular Component	GO:1990597	AIP1-IRE1 complex	IPI	J:136554
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:57921
Cellular Component	GO:1990630	IRE1-RACK1-PP2A complex	ISO	J:164563
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	ISO	J:164563
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IDA	J:192731
Cellular Component	GO:0005637	nuclear inner membrane	IDA	J:107824
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0034620	cellular response to unfolded protein	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	TAS	J:171795
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:95320
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:62257
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:70005
Biological Process	GO:0001935	endothelial cell proliferation	ISO	J:164563
Biological Process	GO:1901142	insulin metabolic process	ISO	J:164563
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:147348
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA	J:265628
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	J:66969
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	IDA	J:255334
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	IBA	J:265628
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	IDA	J:210646
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0006379	mRNA cleavage	IDA	J:255334
Biological Process	GO:0098787	mRNA cleavage involved in mRNA processing	ISO	J:164563
Biological Process	GO:0006397	mRNA processing	IEA	J:72247
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	TAS	J:171795
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ISO	J:164563
Biological Process	GO:1990579	peptidyl-serine trans-autophosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:1904294	positive regulation of ERAD pathway	TAS	J:171795
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:132966
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0033120	positive regulation of RNA splicing	IDA	J:255334
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:255334
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:70005
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000