GO Annotations Graph

• Symbol: Cubn
• Name: cubilin
• ID: MGI:1931256

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:155856
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:164563
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:311657
Molecular Function	GO:0031419	cobalamin binding	IEA	J:60000
Molecular Function	GO:0030492	hemoglobin binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:76353
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	TAS	J:67664
Cellular Component	GO:0045177	apical part of cell	IDA	J:98337
Cellular Component	GO:0045177	apical part of cell	IDA	J:76353
Cellular Component	GO:0045177	apical part of cell	IDA	J:98256
Cellular Component	GO:0016324	apical plasma membrane	NAS	J:311657
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:98256
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:98256
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:98256
Cellular Component	GO:0005903	brush border	IDA	J:84433
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:98256
Cellular Component	GO:0030135	coated vesicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:76353
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:98256
Cellular Component	GO:0030666	endocytic vesicle membrane	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:98256
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:98256
Cellular Component	GO:0005768	endosome	IDA	J:67664
Cellular Component	GO:0005768	endosome	IDA	J:84433
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:98256
Cellular Component	GO:0005798	Golgi-associated vesicle	ISO	J:155856
Cellular Component	GO:0043202	lysosomal lumen	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031528	microvillus membrane	IDA	J:319880
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0042366	cobalamin catabolic process	ISO	J:155856
Biological Process	GO:0015889	cobalamin transport	ISO	J:164563
Biological Process	GO:0015889	cobalamin transport	ISO	J:155856
Biological Process	GO:0015889	cobalamin transport	ISO	J:311657
Biological Process	GO:0020028	endocytic hemoglobin import into cell	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:98256
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:98256
Biological Process	GO:0001701	in utero embryonic development	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0042953	lipoprotein transport	IDA	J:98256
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:98256
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0007584	response to nutrient	ISO	J:155856
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000