Pycard GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pycard
PYD and CARD domain containing
MGI:1931465

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070700	BMP receptor binding	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:219619
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0017024	myosin I binding	ISO	J:164563
Molecular Function	GO:0016505	peptidase activator activity involved in apoptotic process	ISO	J:66971
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:192821
Molecular Function	GO:0005515	protein binding	IPI	J:186690
Molecular Function	GO:0005515	protein binding	IPI	J:245276
Molecular Function	GO:0005515	protein binding	IPI	J:91292
Molecular Function	GO:0005515	protein binding	IPI	J:145965
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0046983	protein dimerization activity	IMP	J:219619
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0032090	Pyrin domain binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0005523	tropomyosin binding	ISO	J:164563
Cellular Component	GO:0097169	AIM2 inflammasome complex	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	IBA	J:265628
Cellular Component	GO:0061702	canonical inflammasome complex	IDA	J:295244
Cellular Component	GO:0005737	cytoplasm	NAS	J:319953
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	NAS	J:158968
Cellular Component	GO:0005737	cytoplasm	ISO	J:145965
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-877385
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-877388
Cellular Component	GO:0005829	cytosol	IDA	J:66971
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IDA	J:91292
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0008385	IkappaB kinase complex	ISO	J:164563
Cellular Component	GO:0005874	microtubule	NAS	J:263129
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0072558	NLRP1 inflammasome complex	ISO	J:164563
Cellular Component	GO:0072559	NLRP3 inflammasome complex	ISO	J:164563
Cellular Component	GO:0140738	NLRP6 inflammasome complex	ISO	J:164563
Cellular Component	GO:0140738	NLRP6 inflammasome complex	IDA	J:316943
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:219619
Cellular Component	GO:0005634	nucleus	IDA	J:176441
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	IMP	J:197219
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:117613
Biological Process	GO:0002218	activation of innate immune response	IMP	J:146958
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:66971
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:295244
Biological Process	GO:0051607	defense response to virus	NAS	J:158968
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:91292
Biological Process	GO:0045087	innate immune response	IEA	J:72247
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	ISO	J:164563
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:164563
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:193522
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:193522
Biological Process	GO:0044351	macropinocytosis	IMP	J:176441
Biological Process	GO:0001773	myeloid dendritic cell activation	ISO	J:164563
Biological Process	GO:0002277	myeloid dendritic cell activation involved in immune response	IMP	J:176441
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0032688	negative regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0007231	osmosensory signaling pathway	NAS	J:187661
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:319676
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:320140
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:158968
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:176441
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IMP	J:176441
Biological Process	GO:0002821	positive regulation of adaptive immune response	ISO	J:164563
Biological Process	GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	IMP	J:176441
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:190277
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IMP	J:146958
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:190277
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:257673
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:158968
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:259950
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:259950
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:257673
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:146958
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:205949
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:176441
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:193522
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:193522
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:176441
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	ISO	J:164563
Biological Process	GO:2000406	positive regulation of T cell migration	IMP	J:176441
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:176441
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0070269	pyroptosis	NAS	J:158968
Biological Process	GO:0070269	pyroptosis	NAS	J:229325
Biological Process	GO:0070269	pyroptosis	NAS	J:319676
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:91292
Biological Process	GO:0010506	regulation of autophagy	IMP	J:212020
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:91292
Biological Process	GO:0043087	regulation of GTPase activity	IMP	J:176441
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:181354
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:193522
Biological Process	GO:2001242	regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	IMP	J:176441
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IMP	J:212020
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24