GO Annotations Graph

• Symbol: Dhx58
• Name: DExH-box helicase 58
• ID: MGI:1931560

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	IBA	J:265628
Molecular Function	GO:0003725	double-stranded RNA binding	IDA	J:173994
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0003724	RNA helicase activity	ISO	J:164563
Molecular Function	GO:0003727	single-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0003727	single-stranded RNA binding	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:73270
Biological Process	GO:0140374	antiviral innate immune response	IBA	J:265628
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:183197
Biological Process	GO:0039534	negative regulation of MDA-5 signaling pathway	ISO	J:164563
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	IMP	J:146113
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	ISO	J:164563
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	IBA	J:265628
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032480	negative regulation of type I interferon production	IMP	J:183197
Biological Process	GO:1900245	positive regulation of MDA-5 signaling pathway	IMP	J:156867
Biological Process	GO:1900246	positive regulation of RIG-I signaling pathway	IMP	J:156867
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:156867
Biological Process	GO:0045088	regulation of innate immune response	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0009615	response to virus	IMP	J:156867