GO Annotations Graph

• Symbol: Egln2
• Name: egl-9 family hypoxia-inducible factor 2
• ID: MGI:1932287

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	ISO	J:73065
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0008198	ferrous iron binding	IBA	J:265628
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0031418	L-ascorbic acid binding	IEA	J:72247
Molecular Function	GO:0031418	L-ascorbic acid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	J:72247
Molecular Function	GO:0019826	oxygen sensor activity	ISO	J:164563
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity	ISO	J:155856
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity	ISO	J:164563
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	IBA	J:265628
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISO	J:164563
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISO	J:155856
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IBA	J:265628
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0043523	regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563