GO Annotations Graph

• Symbol: Tlr9
• Name: toll-like receptor 9
• ID: MGI:1932389

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:164563
Molecular Function	GO:0038187	pattern recognition receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:143561
Molecular Function	GO:0005515	protein binding	IPI	J:224870
Molecular Function	GO:0005515	protein binding	IPI	J:217243
Molecular Function	GO:0005515	protein binding	IPI	J:143338
Molecular Function	GO:0005515	protein binding	IPI	J:161113
Molecular Function	GO:0005515	protein binding	IPI	J:179457
Molecular Function	GO:0035197	siRNA binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0045322	unmethylated CpG binding	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0032009	early phagosome	IDA	J:132643
Cellular Component	GO:0036019	endolysosome	IMP	J:143561
Cellular Component	GO:0036019	endolysosome	IDA	J:269559
Cellular Component	GO:0036019	endolysosome	IGI	J:143338
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:132643
Cellular Component	GO:0005768	endosome	IDA	J:132643
Cellular Component	GO:0005768	endosome	IDA	J:163984
Cellular Component	GO:0005764	lysosome	IDA	J:143338
Cellular Component	GO:0005764	lysosome	IDA	J:132643
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045335	phagocytic vesicle	IGI	J:143338
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:105484
Cellular Component	GO:0005886	plasma membrane	ISS	J:66049
Biological Process	GO:0002218	activation of innate immune response	IDA	J:240584
Biological Process	GO:1902350	cellular response to chloroquine	IDA	J:146128
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	ISO	J:155856
Biological Process	GO:0051607	defense response to virus	IBA	J:265628
Biological Process	GO:0051607	defense response to virus	IGI	J:131989
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:143338
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0007252	I-kappaB phosphorylation	ISO	J:164563
Biological Process	GO:0006955	immune response	IMP	J:66049
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	TAS	J:161025
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	IMP	J:154827
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IPI	J:143338
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:211913
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:131398
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:155856
Biological Process	GO:0050871	positive regulation of B cell activation	ISO	J:164563
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	IDA	J:240588
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IEA	J:72247
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	IDA	J:161025
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IDA	J:161025
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:161025
Biological Process	GO:0032741	positive regulation of interleukin-18 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IBA	J:265628
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:240584
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	J:161025
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	IMP	J:143561
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:154827
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:161025
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:143561
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:161025
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0050864	regulation of B cell activation	IGI	J:211913
Biological Process	GO:0045577	regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0001817	regulation of cytokine production	IEA	J:72247
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	IDA	J:143745
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:131398
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:215205
Biological Process	GO:0034163	regulation of toll-like receptor 9 signaling pathway	ISO	J:164563
Biological Process	GO:0002237	response to molecule of bacterial origin	TAS	J:161025
Biological Process	GO:0009615	response to virus	IMP	J:88906
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628