GO Annotations Graph

• Symbol: Letm1
• Name: leucine zipper-EF-hand containing transmembrane protein 1
• ID: MGI:1932557

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0015369	calcium:proton antiporter activity	IDA	J:241038
Molecular Function	GO:0015369	calcium:proton antiporter activity	IMP	J:222017
Molecular Function	GO:0015369	calcium:proton antiporter activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0043022	ribosome binding	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:241038
Cellular Component	GO:0005743	mitochondrial inner membrane	TAS	Reactome:R-MMU-8951834
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005739	mitochondrion	IDA	J:86816
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0099093	calcium export from the mitochondrion	IDA	J:241038
Biological Process	GO:0099093	calcium export from the mitochondrion	IMP	J:222017
Biological Process	GO:0099093	calcium export from the mitochondrion	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0042407	cristae formation	ISO	J:164563
Biological Process	GO:0007007	inner mitochondrial membrane organization	ISO	J:164563
Biological Process	GO:0030003	intracellular monoatomic cation homeostasis	IBA	J:265628
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	IDA	J:241038
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	IDA	J:241038
Biological Process	GO:0140141	mitochondrial potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0051562	negative regulation of mitochondrial calcium ion concentration	ISO	J:164563
Biological Process	GO:0034214	protein hexamerization	IDA	J:241038
Biological Process	GO:0051260	protein homooligomerization	IDA	J:241038
Biological Process	GO:1900069	regulation of cellular hyperosmotic salinity response	ISO	J:164563