GO Annotations Graph

• Symbol: Pik3ap1
• Name: phosphoinositide-3-kinase adaptor protein 1
• ID: MGI:1933177

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	IPI	J:114108
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IDA	J:196267
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IDA	J:180127
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:180126
Molecular Function	GO:0005515	protein binding	IPI	J:66479
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:66479
Cellular Component	GO:0005829	cytosol	IDA	J:180127
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:180127
Cellular Component	GO:0005886	plasma membrane	IDA	J:66479
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:196267
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP	J:180126
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP	J:180127
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	IMP	J:196267
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:180126
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IMP	J:180126
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IMP	J:180126
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IMP	J:180127
Biological Process	GO:0034154	toll-like receptor 7 signaling pathway	IMP	J:180127
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	IMP	J:180127
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	IMP	J:180126