GO Annotations Graph

• Symbol: Erap1
• Name: endoplasmic reticulum aminopeptidase 1
• ID: MGI:1933403

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004177	aminopeptidase activity	ISO	J:164563
Molecular Function	GO:0004177	aminopeptidase activity	ISO	J:155856
Molecular Function	GO:0004177	aminopeptidase activity	IDA	J:68745
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070006	metalloaminopeptidase activity	IBA	J:265628
Molecular Function	GO:0008235	metalloexopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IMP	J:204785
Molecular Function	GO:0042277	peptide binding	IBA	J:265628
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:68745
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005788	endoplasmic reticulum lumen	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0043171	peptide catabolic process	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:68745
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IDA	J:204785
Biological Process	GO:0008217	regulation of blood pressure	IEA	J:72247