GO Annotations Graph

• Symbol: Jam3
• Name: junction adhesion molecule 3
• ID: MGI:1933825

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	ISO	J:164563
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:106527
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IPI	J:106527
Molecular Function	GO:0005178	integrin binding	IPI	J:106527
Molecular Function	GO:0005515	protein binding	IPI	J:128950
Molecular Function	GO:0005515	protein binding	IPI	J:128950
Molecular Function	GO:0005515	protein binding	IPI	J:106527
Molecular Function	GO:0005515	protein binding	IPI	J:107896
Molecular Function	GO:0046982	protein heterodimerization activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IEA	J:72247
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:137255
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:78942
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0044291	cell-cell contact zone	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:118544
Cellular Component	GO:0005911	cell-cell junction	IDA	J:106527
Cellular Component	GO:0005911	cell-cell junction	IDA	J:137255
Cellular Component	GO:0005911	cell-cell junction	IDA	J:92665
Cellular Component	GO:0005911	cell-cell junction	IDA	J:137255
Cellular Component	GO:0030057	desmosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0031941	filamentous actin	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0033010	paranodal junction	IDA	J:170257
Cellular Component	GO:0033010	paranodal junction	IDA	J:127609
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098636	protein complex involved in cell adhesion	ISO	J:164563
Cellular Component	GO:0098636	protein complex involved in cell adhesion	IBA	J:265628
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	IDA	J:170257
Cellular Component	GO:0070160	tight junction	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IMP	J:147736
Biological Process	GO:0034333	adherens junction assembly	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IDA	J:172999
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0045176	apical protein localization	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IGI	J:106527
Biological Process	GO:0007155	cell adhesion	IGI	J:106527
Biological Process	GO:0007155	cell adhesion	IGI	J:147736
Biological Process	GO:0007155	cell adhesion	ISO	J:78942
Biological Process	GO:0007155	cell adhesion	IGI	J:147736
Biological Process	GO:0007155	cell adhesion	IGI	J:106527
Biological Process	GO:0007155	cell adhesion	IMP	J:106527
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	IDA	J:118544
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:225263
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IDA	J:118544
Biological Process	GO:0007160	cell-matrix adhesion	IGI	J:118544
Biological Process	GO:0007160	cell-matrix adhesion	IGI	J:118544
Biological Process	GO:0030010	establishment of cell polarity	IDA	J:118544
Biological Process	GO:0097530	granulocyte migration	ISO	J:164563
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	IMP	J:225263
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	ISO	J:164563
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IMP	J:99020
Biological Process	GO:0042552	myelination	IMP	J:127609
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IMP	J:145994
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0033624	negative regulation of integrin activation	ISO	J:164563
Biological Process	GO:0001780	neutrophil homeostasis	IMP	J:121841
Biological Process	GO:0002693	positive regulation of cellular extravasation	ISO	J:164563
Biological Process	GO:1905710	positive regulation of membrane permeability	ISO	J:164563
Biological Process	GO:1902414	protein localization to cell junction	ISO	J:164563
Biological Process	GO:0034394	protein localization to cell surface	ISO	J:164563
Biological Process	GO:0090138	regulation of actin cytoskeleton organization by cell-cell adhesion	IMP	J:92665
Biological Process	GO:0090022	regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0007286	spermatid development	IMP	J:92665
Biological Process	GO:0007283	spermatogenesis	IMP	J:92665
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:127609