GO Annotations Graph

• Symbol: Usp8
• Name: ubiquitin specific peptidase 8
• ID: MGI:1934029

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:107114
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:163444
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:73065
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:193088
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:72190
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:163444
Molecular Function	GO:0005515	protein binding	IPI	J:107114
Molecular Function	GO:0005515	protein binding	IPI	J:92790
Molecular Function	GO:0005515	protein binding	IPI	J:68972
Molecular Function	GO:0005515	protein binding	IPI	J:68972
Molecular Function	GO:0005515	protein binding	IPI	J:193088
Molecular Function	GO:0005515	protein binding	IPI	J:68972
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Cellular Component	GO:0002080	acrosomal membrane	IDA	J:193088
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:107114
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0031313	extrinsic component of endosome membrane	IDA	J:107114
Cellular Component	GO:0031313	extrinsic component of endosome membrane	IBA	J:265628
Cellular Component	GO:0019897	extrinsic component of plasma membrane	ISO	J:164563
Cellular Component	GO:0019897	extrinsic component of plasma membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:72190
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030496	midbody	IBA	J:265628
Cellular Component	GO:0030496	midbody	ISO	J:73065
Cellular Component	GO:0030496	midbody	IDA	J:139593
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:155856
Biological Process	GO:0007032	endosome organization	ISO	J:164563
Biological Process	GO:0007032	endosome organization	IMP	J:163444
Biological Process	GO:0007032	endosome organization	IBA	J:265628
Biological Process	GO:0000281	mitotic cytokinesis	ISO	J:73065
Biological Process	GO:1905166	negative regulation of lysosomal protein catabolic process	ISO	J:164563
Biological Process	GO:1905908	positive regulation of amyloid fibril formation	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	IMP	J:92790
Biological Process	GO:0016579	protein deubiquitination	IDA	J:107114
Biological Process	GO:0016579	protein deubiquitination	IDA	J:163444
Biological Process	GO:0016579	protein deubiquitination	IDA	J:193088
Biological Process	GO:0016579	protein deubiquitination	ISO	J:73065
Biological Process	GO:0071108	protein K48-linked deubiquitination	ISO	J:164563
Biological Process	GO:0071108	protein K48-linked deubiquitination	IBA	J:265628
Biological Process	GO:0070536	protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0070536	protein K63-linked deubiquitination	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0007265	Ras protein signal transduction	IPI	J:72190
Biological Process	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	J:72247