GO Annotations Graph

• Symbol: Park7
• Name: Parkinson disease (autosomal recessive, early onset) 7
• ID: MGI:2135637

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:1903135	cupric ion binding	ISO	J:164563
Molecular Function	GO:1903136	cuprous ion binding	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:1990422	glyoxalase (glycolic acid-forming) activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0036478	L-dopa decarboxylase activator activity	ISO	J:164563
Molecular Function	GO:0045340	mercury ion binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0050681	nuclear androgen receptor binding	ISO	J:164563
Molecular Function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	ISO	J:164563
Molecular Function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	IBA	J:265628
Molecular Function	GO:0019826	oxygen sensor activity	IMP	J:125021
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0051920	peroxiredoxin activity	IMP	J:125021
Molecular Function	GO:0005515	protein binding	IPI	J:282679
Molecular Function	GO:0005515	protein binding	IPI	J:211328
Molecular Function	GO:0005515	protein binding	IPI	J:239193
Molecular Function	GO:0005515	protein binding	IPI	J:233583
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	TAS	J:69175
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0044388	small protein activating enzyme binding	ISO	J:164563
Molecular Function	GO:0016532	superoxide dismutase copper chaperone activity	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0036470	tyrosine 3-monooxygenase activator activity	ISO	J:164563
Molecular Function	GO:0044390	ubiquitin-like protein conjugating enzyme binding	ISO	J:164563
Molecular Function	GO:1990381	ubiquitin-specific protease binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0044297	cell body	IDA	J:211328
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	IDA	J:211455
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:210919
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:204791
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:282679
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:204791
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005758	mitochondrial intermembrane space	IDA	J:210919
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:210919
Cellular Component	GO:0005739	mitochondrion	IDA	J:210919
Cellular Component	GO:0005739	mitochondrion	IDA	J:282679
Cellular Component	GO:0005739	mitochondrion	IDA	J:211455
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:125021
Cellular Component	GO:0005739	mitochondrion	IDA	J:204791
Cellular Component	GO:0043005	neuron projection	IDA	J:211328
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:204791
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0098793	presynapse	IMP	J:98436
Cellular Component	GO:0061827	sperm head	ISO	J:155856
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:98436
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:99905
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0110095	cellular detoxification of aldehyde	ISO	J:164563
Biological Process	GO:0140041	cellular detoxification of methylglyoxal	ISO	J:164563
Biological Process	GO:0036471	cellular response to glyoxal	ISO	J:164563
Biological Process	GO:0036471	cellular response to glyoxal	IMP	J:212785
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:97366
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:168618
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	IMP	J:111114
Biological Process	GO:0070994	detection of oxidative stress	IMP	J:125021
Biological Process	GO:0010273	detoxification of copper ion	ISO	J:164563
Biological Process	GO:0010273	detoxification of copper ion	IMP	J:201915
Biological Process	GO:0050787	detoxification of mercury ion	IMP	J:201915
Biological Process	GO:0050787	detoxification of mercury ion	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0051583	dopamine uptake involved in synaptic transmission	IMP	J:98436
Biological Process	GO:0042593	glucose homeostasis	IMP	J:243391
Biological Process	GO:0036531	glutathione deglycation	ISO	J:164563
Biological Process	GO:0046295	glycolate biosynthetic process	ISO	J:164563
Biological Process	GO:0046295	glycolate biosynthetic process	IDA	J:212785
Biological Process	GO:0046295	glycolate biosynthetic process	IBA	J:265628
Biological Process	GO:1903189	glyoxal metabolic process	ISO	J:164563
Biological Process	GO:1903189	glyoxal metabolic process	IDA	J:212785
Biological Process	GO:1903189	glyoxal metabolic process	IBA	J:265628
Biological Process	GO:0106044	guanine deglycation	ISO	J:164563
Biological Process	GO:0106046	guanine deglycation, glyoxal removal	ISO	J:164563
Biological Process	GO:0106045	guanine deglycation, methylglyoxal removal	ISO	J:164563
Biological Process	GO:0042743	hydrogen peroxide metabolic process	ISO	J:164563
Biological Process	GO:0042743	hydrogen peroxide metabolic process	IMP	J:125021
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0030073	insulin secretion	IMP	J:243391
Biological Process	GO:0019249	lactate biosynthetic process	ISO	J:164563
Biological Process	GO:0051899	membrane depolarization	IMP	J:111114
Biological Process	GO:0060081	membrane hyperpolarization	IMP	J:111114
Biological Process	GO:0061727	methylglyoxal catabolic process to lactate	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	IMP	J:157910
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:212785
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:97366
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:217286
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	ISO	J:164563
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	ISO	J:164563
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	IMP	J:211328
Biological Process	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IMP	J:217286
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	IBA	J:265628
Biological Process	GO:1905259	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1904782	negative regulation of NMDA glutamate receptor activity	ISO	J:155856
Biological Process	GO:1903202	negative regulation of oxidative stress-induced cell death	ISO	J:164563
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	IMP	J:211627
Biological Process	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:1901984	negative regulation of protein acetylation	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0042177	negative regulation of protein catabolic process	IMP	J:211627
Biological Process	GO:0046826	negative regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:1903094	negative regulation of protein K48-linked deubiquitination	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0033234	negative regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IMP	J:211627
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	IMP	J:243391
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1903122	negative regulation of TRAIL-activated apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	IC	J:211627
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:2000157	negative regulation of ubiquitin-specific protease activity	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0036527	peptidyl-arginine deglycation	ISO	J:164563
Biological Process	GO:0036526	peptidyl-cysteine deglycation	ISO	J:164563
Biological Process	GO:0036528	peptidyl-lysine deglycation	ISO	J:164563
Biological Process	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	IMP	J:239193
Biological Process	GO:2000825	positive regulation of androgen receptor activity	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:1903181	positive regulation of dopamine biosynthetic process	ISO	J:164563
Biological Process	GO:1905516	positive regulation of fertilization	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:184611
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:1903197	positive regulation of L-dopa biosynthetic process	ISO	J:164563
Biological Process	GO:1903200	positive regulation of L-dopa decarboxylase activity	ISO	J:164563
Biological Process	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	ISO	J:164563
Biological Process	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP	J:212799
Biological Process	GO:0033864	positive regulation of NAD(P)H oxidase activity	IMP	J:239193
Biological Process	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	IMP	J:168618
Biological Process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	J:204791
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:1903168	positive regulation of pyrroline-5-carboxylate reductase activity	ISO	J:164563
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	IDA	J:204791
Biological Process	GO:1901671	positive regulation of superoxide dismutase activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:211242
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:169897
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:1903178	positive regulation of tyrosine 3-monooxygenase activity	ISO	J:164563
Biological Process	GO:0036529	protein deglycation, glyoxal removal	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:146282
Biological Process	GO:0050821	protein stabilization	IMP	J:169897
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0060765	regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:169981
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:0043523	regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:97366
Biological Process	GO:0042542	response to hydrogen peroxide	IDA	J:97366
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IBA	J:265628
Biological Process	GO:0007338	single fertilization	IEA	J:60000
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:99905