GO Annotations Graph

• Symbol: Scap
• Name: SREBF chaperone
• ID: MGI:2135958

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	TAS	J:69592
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:79403
Molecular Function	GO:0005515	protein binding	IPI	J:79403
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0032934	sterol binding	IEA	J:72247
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:79403
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032936	SREBP-SCAP complex	IBA	J:265628
Biological Process	GO:0044255	cellular lipid metabolic process	IMP	J:181551
Biological Process	GO:0008203	cholesterol metabolic process	IDA	J:69592
Biological Process	GO:0006955	immune response	IMP	J:181551
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	IBA	J:265628
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	IMP	J:129815
Biological Process	GO:0042304	regulation of fatty acid biosynthetic process	IMP	J:129815
Biological Process	GO:0019217	regulation of fatty acid metabolic process	IDA	J:69592
Biological Process	GO:0001666	response to hypoxia	IMP	J:128622
Biological Process	GO:0032868	response to insulin	IMP	J:129815
Biological Process	GO:0032933	SREBP signaling pathway	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000