GO Annotations Graph

• Symbol: Pias4
• Name: protein inhibitor of activated STAT 4
• ID: MGI:2136940

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:73179
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:73179
Molecular Function	GO:0005515	protein binding	IPI	J:112691
Molecular Function	GO:0005515	protein binding	IPI	J:159937
Molecular Function	GO:0061665	SUMO ligase activity	IDA	J:168276
Molecular Function	GO:0061665	SUMO ligase activity	ISO	J:164563
Molecular Function	GO:0061665	SUMO ligase activity	IBA	J:265628
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	TAS	Reactome:R-MMU-4755534
Molecular Function	GO:0019789	SUMO transferase activity	IDA	J:73179
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:73179
Molecular Function	GO:0003714	transcription corepressor activity	ISA	J:63546
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:172990
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	IDA	J:73179
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-4755534
Cellular Component	GO:0005654	nucleoplasm	IDA	J:107109
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:73179
Cellular Component	GO:1990234	transferase complex	IDA	J:168276
Biological Process	GO:0007417	central nervous system development	IEP	J:63546
Biological Process	GO:0001942	hair follicle development	IEP	J:63546
Biological Process	GO:0060887	limb epidermis development	IEP	J:63546
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IDA	J:172990
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:168276
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:73179
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:159937
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IDA	J:172990
Biological Process	GO:1902174	positive regulation of keratinocyte apoptotic process	IDA	J:172990
Biological Process	GO:0033235	positive regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:0016925	protein sumoylation	ISO	J:164563
Biological Process	GO:0016925	protein sumoylation	IDA	J:168276
Biological Process	GO:0016925	protein sumoylation	IBA	J:265628
Biological Process	GO:0016925	protein sumoylation	IDA	J:73179
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISA	J:63546
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000