GO Annotations Graph

• Symbol: Twnk
• Name: twinkle mtDNA helicase
• ID: MGI:2137410

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043139	5'-3' DNA helicase activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003678	DNA helicase activity	IBA	J:265628
Molecular Function	GO:0003678	DNA helicase activity	IDA	J:70274
Molecular Function	GO:0003678	DNA helicase activity	ISA	J:70274
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	IBA	J:265628
Cellular Component	GO:0042645	mitochondrial nucleoid	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:70274
Biological Process	GO:0006260	DNA replication	IEA	J:72247
Biological Process	GO:0006260	DNA replication	IEA	J:60000
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	ISO	J:164563
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	IDA	J:70274
Biological Process	GO:0006264	mitochondrial DNA replication	ISO	J:164563
Biological Process	GO:0006264	mitochondrial DNA replication	IMP	J:143262
Biological Process	GO:0006264	mitochondrial DNA replication	IBA	J:265628
Biological Process	GO:0006390	mitochondrial transcription	ISO	J:164563
Biological Process	GO:0034214	protein hexamerization	ISO	J:164563