GO Annotations Graph

• Symbol: Slc24a3
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
• ID: MGI:2137513

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0005262	calcium channel activity	IBA	J:265628
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	ISO	J:164563
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	ISO	J:155856
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	IBA	J:265628
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	ISS	J:70136
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	IDA	J:70136
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Cellular Component	GO:0071944	cell periphery	IDA	J:150732
Cellular Component	GO:0071944	cell periphery	ISO	J:155856
Cellular Component	GO:0071944	cell periphery	IDA	J:285009
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	J:70136
Biological Process	GO:0030282	bone mineralization	IMP	J:254307
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	IDA	J:70136
Biological Process	GO:0070588	calcium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:254307
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0006874	intracellular calcium ion homeostasis	TAS	J:70136
Biological Process	GO:0006812	monoatomic cation transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:254307
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:254307
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:254307
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:254307
Biological Process	GO:0071805	potassium ion transmembrane transport	IDA	J:70136
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IDA	J:70136
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247