GO Annotations Graph

• Symbol: Twsg1
• Name: twisted gastrulation BMP signaling modulator 1
• ID: MGI:2137520

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008201	heparin binding	IDA	J:95191
Molecular Function	GO:0005515	protein binding	IPI	J:95191
Molecular Function	GO:0005515	protein binding	IPI	J:95191
Molecular Function	GO:0005515	protein binding	IPI	J:95191
Molecular Function	GO:0005515	protein binding	IPI	J:98379
Molecular Function	GO:0005515	protein binding	IPI	J:95191
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:98069
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:90398
Biological Process	GO:0043010	camera-type eye development	IGI	J:90398
Biological Process	GO:0043010	camera-type eye development	IGI	J:90398
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:90398
Biological Process	GO:0009790	embryo development	IMP	J:88784
Biological Process	GO:0009790	embryo development	IMP	J:88784
Biological Process	GO:0030900	forebrain development	IGI	J:90398
Biological Process	GO:0030900	forebrain development	IMP	J:88784
Biological Process	GO:0030097	hemopoiesis	IMP	J:82738
Biological Process	GO:0001707	mesoderm formation	IGI	J:98379
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:82738
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:98069
Biological Process	GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	ISO	J:164563
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO	J:164563
Biological Process	GO:0001818	negative regulation of cytokine production	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IDA	J:98069
Biological Process	GO:0001503	ossification	IMP	J:82738
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IMP	J:82738
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0030510	regulation of BMP signaling pathway	IBA	J:265628
Biological Process	GO:0007435	salivary gland morphogenesis	IMP	J:144153
Biological Process	GO:0009888	tissue development	IGI	J:90398
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563