GO Annotations Graph

• Symbol: Kmo
• Name: kynurenine 3-monooxygenase
• ID: MGI:2138151

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071949	FAD binding	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:164563
Molecular Function	GO:0004502	kynurenine 3-monooxygenase activity	ISO	J:155856
Molecular Function	GO:0004502	kynurenine 3-monooxygenase activity	IMP	J:233151
Molecular Function	GO:0004502	kynurenine 3-monooxygenase activity	ISO	J:164563
Molecular Function	GO:0004502	kynurenine 3-monooxygenase activity	IBA	J:265628
Molecular Function	GO:0004497	monooxygenase activity	IEA	J:60000
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0034276	kynurenic acid biosynthetic process	ISO	J:155856
Biological Process	GO:0070189	kynurenine metabolic process	ISO	J:155856
Biological Process	GO:0070189	kynurenine metabolic process	IMP	J:233151
Biological Process	GO:0070189	kynurenine metabolic process	ISO	J:164563
Biological Process	GO:0070189	kynurenine metabolic process	IBA	J:265628
Biological Process	GO:0097052	L-kynurenine metabolic process	ISO	J:155856
Biological Process	GO:0019674	NAD metabolic process	ISO	J:155856
Biological Process	GO:0019674	NAD metabolic process	ISO	J:164563
Biological Process	GO:0014049	positive regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:1903296	positive regulation of glutamate secretion, neurotransmission	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0019363	pyridine nucleotide biosynthetic process	IEA	J:60000
Biological Process	GO:0019805	quinolinate biosynthetic process	IEA	J:72247
Biological Process	GO:0009651	response to salt stress	ISO	J:164563
Biological Process	GO:0006569	tryptophan catabolic process	IEA	J:72247