GO Annotations Graph

• Symbol: Eps8l2
• Name: EPS8-like 2
• ID: MGI:2138828

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	ISO	J:90061
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:90061
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IBA	J:265628
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:200669
Cellular Component	GO:0032426	stereocilium tip	IDA	J:200669
Biological Process	GO:1900029	positive regulation of ruffle assembly	ISO	J:164563
Biological Process	GO:1900029	positive regulation of ruffle assembly	IBA	J:265628
Biological Process	GO:0016601	Rac protein signal transduction	ISO	J:90061
Biological Process	GO:0035023	regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0035023	regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	IDA	J:200669