GO Annotations Graph

• Symbol: Pot1a
• Name: protection of telomeres 1A
• ID: MGI:2141503

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	ISO	J:164563
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:1990955	G-rich single-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:245385
Molecular Function	GO:0005515	protein binding	IPI	J:159142
Molecular Function	GO:0005515	protein binding	IPI	J:115639
Molecular Function	GO:0005515	protein binding	IPI	J:115639
Molecular Function	GO:0043047	single-stranded telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0043047	single-stranded telomeric DNA binding	IDA	J:115639
Molecular Function	GO:0010521	telomerase inhibitor activity	ISO	J:164563
Molecular Function	GO:0010521	telomerase inhibitor activity	IBA	J:265628
Molecular Function	GO:0061821	telomeric D-loop binding	ISO	J:164563
Molecular Function	GO:0042162	telomeric DNA binding	IDA	J:159049
Molecular Function	GO:0042162	telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0042162	telomeric DNA binding	IDA	J:199000
Molecular Function	GO:0042162	telomeric DNA binding	ISO	J:79912
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:199000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:79912
Cellular Component	GO:0000783	nuclear telomere cap complex	ISO	J:164563
Cellular Component	GO:0000783	nuclear telomere cap complex	IBA	J:265628
Cellular Component	GO:0000783	nuclear telomere cap complex	IDA	J:115639
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912355
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0070187	shelterin complex	ISO	J:164563
Biological Process	GO:0051276	chromosome organization	IGI	J:115639
Biological Process	GO:0051276	chromosome organization	IGI	J:115639
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0070200	establishment of protein localization to telomere	ISO	J:164563
Biological Process	GO:0051974	negative regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0051974	negative regulation of telomerase activity	IBA	J:265628
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:1905776	positive regulation of DNA helicase activity	ISO	J:164563
Biological Process	GO:0060383	positive regulation of DNA strand elongation	ISO	J:164563
Biological Process	GO:0051096	positive regulation of helicase activity	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0032206	positive regulation of telomere maintenance	NAS	J:319993
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:1905774	regulation of DNA helicase activity	ISO	J:164563
Biological Process	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	IBA	J:265628
Biological Process	GO:0032202	telomere assembly	ISO	J:164563
Biological Process	GO:0016233	telomere capping	ISO	J:164563
Biological Process	GO:0016233	telomere capping	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	IEA	J:72247
Biological Process	GO:0007004	telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0061820	telomeric D-loop disassembly	ISO	J:164563