GO Annotations Graph

• Symbol: Ap2s1
• Name: adaptor-related protein complex 2, sigma 1 subunit
• ID: MGI:2141861

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035615	clathrin adaptor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:240303
Cellular Component	GO:0030122	AP-2 adaptor complex	ISO	J:155856
Cellular Component	GO:0030122	AP-2 adaptor complex	NAS	J:240303
Cellular Component	GO:0030122	AP-2 adaptor complex	IDA	J:240303
Cellular Component	GO:0030122	AP-2 adaptor complex	ISO	J:73065
Cellular Component	GO:0005905	clathrin-coated pit	IEA	J:60000
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	NAS	J:320128
Cellular Component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030117	membrane coat	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0045202	synapse	IDA	J:263419
Cellular Component	GO:0045202	synapse	EXP	J:263419
Biological Process	GO:0072583	clathrin-dependent endocytosis	NAS	J:320128
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0006886	intracellular protein transport	IEA	J:72247
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	ISO	J:155856
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	NAS	J:319684
Biological Process	GO:0015031	protein transport	IEA	J:72247
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:164563
Biological Process	GO:0016192	vesicle-mediated transport	NAS	J:319992
Biological Process	GO:0016192	vesicle-mediated transport	IBA	J:265628