GO Annotations Graph

• Symbol: Nlrp6
• Name: NLR family, pyrin domain containing 6
• ID: MGI:2141990

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003725	double-stranded RNA binding	IDA	J:316943
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0070891	lipoteichoic acid binding	IDA	J:267416
Molecular Function	GO:0070891	lipoteichoic acid binding	ISO	J:164563
Molecular Function	GO:0070891	lipoteichoic acid binding	IDA	J:316943
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	IDA	J:316943
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0038187	pattern recognition receptor activity	IDA	J:316943
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0042277	peptide binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:227056
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0030546	signaling receptor activator activity	ISO	J:164563
Molecular Function	GO:0005000	vasopressin receptor activity	ISO	J:155856
Molecular Function	GO:0005000	vasopressin receptor activity	IBA	J:265628
Cellular Component	GO:0061702	canonical inflammasome complex	IBA	J:265628
Cellular Component	GO:0061702	canonical inflammasome complex	IDA	J:295244
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0140738	NLRP6 inflammasome complex	IDA	J:316943
Cellular Component	GO:0140738	NLRP6 inflammasome complex	IDA	J:306372
Cellular Component	GO:0140738	NLRP6 inflammasome complex	ISO	J:164563
Cellular Component	GO:0043228	non-membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043228	non-membrane-bounded organelle	IDA	J:316943
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	IMP	J:295244
Biological Process	GO:0002526	acute inflammatory response	IBA	J:265628
Biological Process	GO:0002526	acute inflammatory response	IMP	J:295244
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	IMP	J:295244
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0140374	antiviral innate immune response	IDA	J:316943
Biological Process	GO:0140374	antiviral innate immune response	IMP	J:227056
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:267416
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:227056
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	IMP	J:227991
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:295244
Biological Process	GO:0032621	interleukin-18 production	IMP	J:295244
Biological Process	GO:0070266	necroptotic process	IMP	J:295244
Biological Process	GO:0070266	necroptotic process	IMP	J:295244
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:186698
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:186698
Biological Process	GO:0050777	negative regulation of immune response	IMP	J:186698
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IMP	J:186698
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:186698
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:186698
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:295244
Biological Process	GO:0070946	neutrophil-mediated killing of gram-positive bacterium	IMP	J:295244
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	IDA	J:316943
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	IDA	J:306372
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:227056
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IDA	J:267416
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IDA	J:316943
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IMP	J:227991
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	IDA	J:316943
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	IDA	J:316943
Biological Process	GO:0070269	pyroptosis	IMP	J:295244
Biological Process	GO:0070269	pyroptosis	IMP	J:295244
Biological Process	GO:0010506	regulation of autophagy	IMP	J:212020
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:175503
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:197406
Biological Process	GO:0070255	regulation of mucus secretion	IMP	J:212020
Biological Process	GO:0009617	response to bacterium	IBA	J:265628
Biological Process	GO:0009617	response to bacterium	IMP	J:212020
Biological Process	GO:0009617	response to bacterium	IMP	J:197406
Biological Process	GO:0009617	response to bacterium	IMP	J:189217
Biological Process	GO:0042060	wound healing	IMP	J:173352