GO Annotations Graph

• Symbol: Ano1
• Name: anoctamin 1, calcium activated chloride channel
• ID: MGI:2142149

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:164563
Molecular Function	GO:0005254	chloride channel activity	ISO	J:164563
Molecular Function	GO:0005254	chloride channel activity	IMP	J:221546
Molecular Function	GO:0005254	chloride channel activity	IDA	J:295452
Molecular Function	GO:0005254	chloride channel activity	IDA	J:276557
Molecular Function	GO:0005254	chloride channel activity	IMP	J:255382
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:297325
Molecular Function	GO:0042802	identical protein binding	IPI	J:297326
Molecular Function	GO:0042802	identical protein binding	IPI	J:196141
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:141010
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:191353
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	ISO	J:155856
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:190271
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:276378
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	ISO	J:164563
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IBA	J:265628
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:198369
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:165954
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:196141
Molecular Function	GO:0005229	intracellular calcium activated chloride channel activity	IDA	J:198369
Molecular Function	GO:0015111	iodide transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0015111	iodide transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:196141
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:276378
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0005247	voltage-gated chloride channel activity	IDA	J:191353
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:173937
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0034707	chloride channel complex	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:196141
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326502
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326502
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326502
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:276378
Cellular Component	GO:0005886	plasma membrane	IDA	J:138613
Cellular Component	GO:0005886	plasma membrane	IDA	J:190271
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9714790
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:165954
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:326502
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:326502
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:326502
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0034605	cellular response to heat	IDA	J:191353
Biological Process	GO:1901653	cellular response to peptide	ISO	J:155856
Biological Process	GO:1902476	chloride transmembrane transport	IMP	J:221546
Biological Process	GO:1902476	chloride transmembrane transport	ISO	J:164563
Biological Process	GO:1902476	chloride transmembrane transport	IDA	J:191353
Biological Process	GO:1902476	chloride transmembrane transport	IDA	J:276378
Biological Process	GO:1902476	chloride transmembrane transport	ISO	J:155856
Biological Process	GO:1902476	chloride transmembrane transport	IBA	J:265628
Biological Process	GO:0006821	chloride transport	ISO	J:155856
Biological Process	GO:0006821	chloride transport	IMP	J:255382
Biological Process	GO:0006821	chloride transport	ISO	J:164563
Biological Process	GO:0006821	chloride transport	IDA	J:141010
Biological Process	GO:0006821	chloride transport	IDA	J:165954
Biological Process	GO:0006821	chloride transport	IDA	J:198369
Biological Process	GO:0006821	chloride transport	IDA	J:198369
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IMP	J:191353
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IGI	J:191353
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:198369
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:198369
Biological Process	GO:0106091	glial cell projection elongation	IMP	J:276557
Biological Process	GO:0015705	iodide transport	ISO	J:164563
Biological Process	GO:0015705	iodide transport	ISO	J:155856
Biological Process	GO:0006812	monoatomic cation transport	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0070254	mucus secretion	ISO	J:164563
Biological Process	GO:0070254	mucus secretion	IMP	J:287874
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	J:191353
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:221546
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0072657	protein localization to membrane	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:192254
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:192254
Biological Process	GO:0060438	trachea development	IMP	J:138613